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Evaluation of a human diploid cell strain rabies vaccine: final report of a three year study of pre-exposure immunization

Published online by Cambridge University Press:  25 March 2010

G. S. Turner ,
K. G. Nicholson ,
D. A. J. Tyrrell  and
F. Y. Aoki
G. S. Turner
Affiliation:
Blood Products Laboratory, National Blood Transfusion Service, Elstree, Hertfordshire, England
K. G. Nicholson
Affiliation:
The Medical Research Council, Division of Communicable Diseases, Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, England
D. A. J. Tyrrell
Affiliation:
The Medical Research Council, Division of Communicable Diseases, Clinical Research Centre, Harrow, Middlesex, HA1 3UJ, England
F. Y. Aoki
Affiliation:
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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Summary

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The antibody responses of 194 volunteers were studied for up to 3 years after primary immunization with one, two or three doses of human diploid cell rabies vaccine, administered either in 0·1 ml volumes intradermally (i.d.) or as 1·0 ml intramuscularly (i.m.). Sero-conversion occurred in 95% of subjects after the first injection and in 100% after the second. The highest titres and most durable antibody responses were induced by three injections of vaccine.

Booster doses were administered either by the subcutaneous (s.c.) or i.d. route, after 6, 12 or 24 months to randomly grouped volunteers; these induced responses ≥ 5·0 i.u. per ml in 95% of subjects. The responses were rapid and were neither influenced by the primary regimen nor by the timing and route of the booster dose.

Antibody titres after i.d. immunization were only two-fold lower than those induced by the larger volume of vaccine. The findings suggest that the i.d. route is both effective and economic.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 1 , August 1982 , pp. 101 - 110
Copyright
Copyright © Cambridge University Press 1982

References

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