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Experimental intestinal coliform infections in mice

Published online by Cambridge University Press:  15 May 2009

Frances M. Ashburner  and
Rose Mushin
Frances M. Ashburner
Affiliation:
The School of Bacteriology, University of Melbourne, Parkville, Victoria, Australia
Rose Mushin
Affiliation:
The School of Bacteriology, University of Melbourne, Parkville, Victoria, Australia
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A technique involving the suppression of normal intestinal flora with antibiotics, and the introduction of streptomycin-resistant coliforms was used for the study of infections in mice.

It was shown that Escherichia coli, both the enteropathogenic and normal faecal strains, tend to colonize the upper intestinal tract as well as the lower region. An oral dose of ten or less cells could produce a chronic infection. Infections were asymptomatic even with an initial dose of 109 bacteria. There was no indication of growth advantages for enteropathogenic coliforms in competition with normal.

Type
Research Article
Information
Journal of Hygiene , Volume 60 , Issue 2 , June 1962 , pp. 175 - 181
Copyright
Copyright © Cambridge University Press 1962

References

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