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Field trials of an inactivated oil-adjuvant vaccine against louping-ill (Arbovirus group B)

Published online by Cambridge University Press:  15 May 2009

J. G. Brotherston ,
C. C. Bannatyne ,
A. O. Mathieson  and
T. B. Nicolson
J. G. Brotherston
Affiliation:
Moredun Institute, Edinburgh
C. C. Bannatyne
Affiliation:
Scottish Veterinary Investigation Service
A. O. Mathieson
Affiliation:
Scottish Veterinary Investigation Service
T. B. Nicolson
Affiliation:
Scottish Veterinary Investigation Service
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Summary

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A single dose of inactivated louping-ill oil-adjuvant vaccine elicited a serologically detectable immune response in sheep lasting for at least 1 year. These sheep when exposed to a natural focus of louping-ill virus were completely protected from clinical disease and 1 year after vaccination were able to pass on a substantial maternal immunity to their lambs.

Twenty-nine per cent of unvaccinated sheep, exposed at the same time, died from clinical louping-ill; half of the survivors showed positive sero-conversion and became immune, while the other half remained susceptible. The incidence of fatal encephalomyelitis in sheep which were known to have circulated virus exceeded 50% in 2 out of 3 trials conducted simultaneously in different locations in Scotland in 1969.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 3 , September 1971 , pp. 479 - 489
Copyright
Copyright © Cambridge University Press 1971

References

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