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How are the sub-unit pertussis vaccines to be evaluated?

Published online by Cambridge University Press:  19 October 2009

D. N. Baxter  and
A. C. C. Gibbs
D. N. Baxter
Affiliation:
Department of Community Medicine, Manchester University Medical School, Stopford Building, Oxford Road, Manchester M13 9PT, UK
A. C. C. Gibbs
Affiliation:
Department of Community Medicine, Manchester University Medical School, Stopford Building, Oxford Road, Manchester M13 9PT, UK
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Summary

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Although an effective whooping cough vaccine has been available in the UK since the 1950s, its current association with neurotoxicity has resulted in poor uptake: as a consequence major epidemics (with significant morbidity and mortality) arc still being experienced.

Component (sub-unit) vaccines, which incorporate those antigens thought to be concerned with generating a protective effect, have been developed and are now available for field testing. This paper addresses how such a vaccine might be evaluated, the organization of a trial and the difficulties to be expected.

Type
Research Article
Information
Epidemiology & Infection , Volume 99 , Issue 2 , October 1987 , pp. 477 - 484
Copyright
Copyright © Cambridge University Press 1987

References

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