Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-14T04:29:26.888Z Has data issue: false hasContentIssue false
  • English
  • Français

The incidence of infection with cytomegalovirus in a normal population: A serological study in Greater London

Published online by Cambridge University Press:  15 May 2009

H. Stern  and
S. D. Elek
H. Stern
Affiliation:
Department of Bacteriology, St George's Hospital Medical School, London S. W. 1
S. D. Elek
Affiliation:
Department of Bacteriology, St George's Hospital Medical School, London S. W. 1
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A serological study of cytomegalovirus infection in London shows it to be prevalent. Under 5 years of age only 4% of children have antibodies, but this increases to 15% by 10 years of age and 21% by 15 years. The maximum incidence of 54% is reached by 25–35 years, and this is maintained in the older age groups of the population. In two mixed day schools the incidence of infection was significantly lower than in a boarding school, suggesting that close prolonged contact is required for spread of infection.

Different strains of cytomegalovirus possess common group-specific complement-fixing antigens.

It is suggested that clinical disease caused by cytomegaloviruses is more frequent and more varied than previously believed, although diagnosis may be difficult without virological help.

Type
Research Article
Information
Journal of Hygiene , Volume 63 , Issue 1 , March 1965 , pp. 79 - 87
Copyright
Copyright © Cambridge University Press 1965

References

Ahvenainen, E. K. (1952). Inclusion disease or generalised salivary gland virus infection. Report of 5 cases. Acta path. microbiol. scand. (suppl.), 93, 159.Google ScholarPubMed
Baar, H. S. (1955). Interstitial plasmacellular pneumonia due to Pneumocystis carinii. J. clin. Path. 8, 19.CrossRefGoogle ScholarPubMed
Birdsong, M., Smith, D. E., Mitchell, F. N. & Corey, J. H. (1956). Generalised cytomegalic inclusion disease in newborn infants. J. Amer. med. Ass. 162, 1305.CrossRefGoogle ScholarPubMed
Crome, L. & France, N. E. (1959). Microgyria and cytomegalic inclusion disease in infancy. J. clin. Path. 12, 427.CrossRefGoogle ScholarPubMed
Farber, S. & Wolbach, S. B. (1932). Intranuclear and cytoplasmic inclusions (‘protozoon-like bodies’) in salivary glands and other organs of infants. Amer. J. Path. 8, 123.Google Scholar
Hanshaw, J. B. & Simon, G. (1962). Cytomegaloviruses in the urine of children with hepatomegaly and abnormal liver function tests. Amer. J. Dis. Child. 104, 555.Google Scholar
Hayflick, L. & Moorhead, P. S. (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585.CrossRefGoogle ScholarPubMed
Löwenstein, C. (1907). Über protozoenartige Gebilde in den Organen von Kindern. Zbl. allg. Path. path. Anat. 18, 513.Google Scholar
McCordock, H. A. & Smith, M. G. (1934). Intranuclear inclusions: incidence and possible significance in whooping cough and a variety of other conditions. Amer. J. Dis. Child, 47, 771.CrossRefGoogle Scholar
McElfresh, A. E. & Arey, J. B. (1957). Generalised cytomegalic inclusion disease. J. Pediat. 51, 146.CrossRefGoogle ScholarPubMed
Medearis, D. N. (1957). Cytomegalic inclusion disease: an analysis of the clinical features based on the literature and six additional cases. Pediatrics, 19, 467.CrossRefGoogle ScholarPubMed
Medearis, D. N. (1964). Observations concerning human cytomegalovirus infection and disease. Johns Hopk. Hosp. Bull. 114, 181.Google ScholarPubMed
Nelson, J. S. & Wyatt, J. P. (1959). Salivary gland virus disease. Medicine, Baltimore, 38, 223.CrossRefGoogle ScholarPubMed
Potenza, L. (1954). Cytomegaly (‘protozoa-like cells’) in South American children. Amer. J. clin. Path., Supplement: Program of the International Congress of Clinical Pathology, Washington, D.C., 24, 43.Google Scholar
Potter, E. L. (1957). Placental transmission of viruses. With especial reference to the intrauterine origin of cytomegalic inclusion body disease. Amer. J. Obstet. Gynec. 74, 505.CrossRefGoogle Scholar
Prawirohardjo, S. (1938). Een onderzoek naar het voorkomen van zoogenaamde protozoaire cellen in de organen van kinderen te Batavia. Ned. Tijdschr. Geneesk. 82, 6218.Google Scholar
Rowe, W. P. (1960). Adenovirus and salivary gland virus infections in children. In Viral Infections in Infancy and Childhood, p. 205, ed. Rose, H. M., New York: P. B. Hoeber, Inc.Google Scholar
Rowe, W. P., Hartley, J. W., Waterman, S., Turner, H. C. & Huebner, R. J. (1956). Cytomegalic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids. Proc. Soc. exp. Biol., N. Y., 92, 418.Google Scholar
Rowe, W. P., Hartley, J. W., Cramblett, H. G. & Mastrota, F. M. (1958). Detection of human salivary gland virus in mouth and urine of children. Amer. J. Hyg. 67, 57.Google ScholarPubMed
Seifert, G. & Oehme, J. (1957). Pathologie und Klinik der Cytomegalie. Leipzig: Georg Thieme.Google Scholar
Smith, M. G. (1956). Propagation in tissue cultures of cytopathogenic virus from human salivary gland virus (SGV) disease. Proc. Soc. exp. Biol., N. Y., 92, 424.CrossRefGoogle ScholarPubMed
Smith, M. G. & Vellios, F. (1950). Inclusion disease or generalised salivary gland virus infection. Arch. Path. 50, 862.Google ScholarPubMed
Stern, H., Lambert, H. P. & Shakespeare, W. G. (1963). Isolation of cytomegalovirus in an infant with an angiosarcoma. Arch. Dis. Childh. 38, 626.CrossRefGoogle Scholar
Symmers, W. St C. (1960). Generalised cytomegalic inclusion-body disease associated with Pneumocystis pneumonia in adults. J. clin. Path. 13, 1.CrossRefGoogle ScholarPubMed
Weller, T. H. & Hanshaw, J. B. (1962). Virologic and clinical observations of cytomegalic inclusion disease. New Engl. J. Med. 266, 1233.CrossRefGoogle ScholarPubMed
Weller, T. H., Hanshaw, J. B. & Scott, D. E. (1960). Serologic differentiation of viruses responsible for cytomegalic inclusion disease. Virology, 12, 130.CrossRefGoogle ScholarPubMed
Weller, T. H., Macauley, J. C., Craig, J. M. & Wirth, P. (1957). Isolation of intranuclear inclusion producing agents from infants with illnesses resembling cytomegalic inclusion disease. Proc. Soc. exp. Biol., N. Y., 94, 4.CrossRefGoogle Scholar
Wong, T. & Warner, N. E. (1962). Cytomegalic inclusion disease in adults. Arch. Path. 74, 403.Google ScholarPubMed
Wyatt, J. P., Sexton, J., Lee, R. S. & Pinkerton, H. (1950). Generalised cytomegalic inclusion disease. J. Pediat. 36, 271.CrossRefGoogle ScholarPubMed