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Isolates of Salmonella enterica Enteritidis PT4 with enhanced heat and acid tolerance are more virulent in mice and more invasive in chickens

Published online by Cambridge University Press:  15 May 2009

T. J. Humphrey ,
A. Williams ,
K. McAlpine ,
M. S. Lever ,
J. Guard-Petter  and
J. M. Cox
T. J. Humphrey
Affiliation:
PHLS Food Microbiology Research Unit, Church Lane, Heavitree, Exeter, Devon EX2 5ADUK
A. Williams
Affiliation:
Centre for Applied Microbiology & Research, Porton Down, Salisbury, Wiltshire SP4 0JGUK
K. McAlpine
Affiliation:
PHLS Food Microbiology Research Unit, Church Lane, Heavitree, Exeter, Devon EX2 5ADUK
M. S. Lever
Affiliation:
Centre for Applied Microbiology & Research, Porton Down, Salisbury, Wiltshire SP4 0JGUK
J. Guard-Petter
Affiliation:
United States Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, Georgia 30605, USA
J. M. Cox
Affiliation:
Department of Food Science and Technology, University of New South Wales, New South Wales, Sydney 2052, Australia
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Summary

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Two Enteritidis PT4 isolates which differed in inherent tolerance to heat, acid, H2O2 and the ability to survive on surfaces were used to infect mice, day-old chicks or laying hens. The acid-, heat-, H2O2- and surface-tolerant isolate was more virulent in mice and more invasive in laying hens, particularly in reproductive tissue. However, no significant differences were observed in behaviour in chicks. Both PT4 isolates were able to infect chicks housed in the same room as infected birds, although the heat-tolerant isolate survived significantly better than the heat-sensitive one in aerosols.

Type
Research Article
Information
Epidemiology & Infection , Volume 117 , Issue 1 , August 1996 , pp. 79 - 88
Copyright
Copyright © Cambridge University Press 1996

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