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Measles in developing countries. Part II. The predicted impact of mass vaccination

Published online by Cambridge University Press:  19 October 2009

A. R. Mclean  and
R. M. Anderson
A. R. Mclean
Affiliation:
Parasite Epidemiology Research Group, Department of Pure and Applied Biology, Imperial College, London University, London SW7 2BB
R. M. Anderson
Affiliation:
Parasite Epidemiology Research Group, Department of Pure and Applied Biology, Imperial College, London University, London SW7 2BB
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A mathematical model is developed to mimic the transmission dynamics of the measles virus in communities in the developing world with high population growth rates and high case fatality rates. The model is used to compare the impacts of different mass vaccination programmes upon morbidity and mortality arising from infection by measles virus. Analyses identify three conclusions of practical significance to the design of optimal vaccination programmes. First, there is no single optimum age at which to vaccinate children for all urban and rural communities in developing countries. For a given community the best age at which to vaccinate depends critically on the age distribution of cases of infection prior to the introduction of control measures. Second, numerical studies predict that the introduction of mass vaccination will induce a temporary phase of very low incidence of infection before the system settles to a new pattern of recurrent epidemics. Mass vaccination acts to lengthen the inter-epidemic period in the postvaccination period when compared with that prevailing prior to control. Third, numerical simulations suggest that two-phase and two-stage vaccination programmes are of less benefit than one-stage programmes (achieving comparable coverage) aimed at young children. The paper ends with a discussion of the needs for: improved programmes of data collection; monitoring of the impact of current vaccination programmes; and the development of models that take account of viral transmission dynamics, host demography and economic factors.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 3 , June 1988 , pp. 419 - 442
Copyright
Copyright © Cambridge University Press 1988

References

Anderson, R. M. & Grenfell, B. T. (1985). The control of congenital rubella syndrome by mass vaccination. Lancet ii, 827–828.CrossRefGoogle Scholar
Anderson, R. M. & May, R. M. (1982). Directly transmitted infectious diseases: control by vaccination. Science 215, 1053–1060.CrossRefGoogle ScholarPubMed
Anderson, R. M. & May, R. M. (1985 a). Age related changes in the rate of disease tansmission: implications for the design of vaccination programmes. Epidemiology and Infection 94, 365–436.Google Scholar
Anderson, R. M. & May, R. M. (1985 b). Vaccination and herd immunity to infectious diseases. Nature 318, 323–329.CrossRefGoogle ScholarPubMed
Black, F. L. (1982). The role of herd immunity in control of measles. Yale Journal of Biology and Medicine 55, 351–360.Google ScholarPubMed
Boue, A. (1964). Contribution à l'étude sérologique de l'épidémiologie de la rougeole au Sénégal. Bulletin de la Société Médicate d'Afrique Noire 9, 253–254.Google Scholar
Burden, R. L., Faires, J. D. & Reynolds, R. C. (1978). Numerical Analysis. Second edition, pp. 554–562. Boston, USA: Prindle, Weber & Schmidt.Google Scholar
E.P.I. (1967). Expanded programme on immunisation. Global status report. Weekly Epidemiological Record 62, 241–243.Google Scholar
Fine, P. E. M. & Clarkson, J. A. (1982). Measles in England and Wales. II. The impact of the measles vaccination programme on the distribution of immunity in the population. International Journal of Epidemiology 11, 15–25.CrossRefGoogle ScholarPubMed
Grenfell, B. T. & Anderson, R. M. (1985). The estimation of age-related rates of infection from case notifications and serological data. Epidemiology and Infection 95, 419–436.Google ScholarPubMed
John, T. J., Joseph, A. & Jessudos, J. (1980). Epidemiology and prevention of measles in rural south India. Indian Journal of Medical Research 72, 153–158.Google ScholarPubMed
May, R. M. & Anderson, R. M. (1985). Endemic infections in growing populations. Mathematical Biosciences 77, 141–156.CrossRefGoogle Scholar
McLean, A. R. (1986). Dynamics of childhood infectious diseases in high birthrate countries. Lecture Notes in Biomathematics 65, 171–197.CrossRefGoogle Scholar
McLean, A. R. (1987). Community size and age at infection: how are they related? In Proceedings of the First World Congress of the Bernoulli Society. The Netherlands: Utrecht VNU Press.Google Scholar
McLean, A. R. & Anderson, R. M. (1987). The transmission dynamics of the measles virus in developing countries. Part 1. Epidemiological parameters and patterns. Epidemiology and Infection. (In Press.)Google Scholar
Miller, D. L. (1964). Frequency of complications of measles, 1963. British Medical Journal ii, 75–78.CrossRefGoogle Scholar
Peltola, H., Koronko, V., Kurki, T., Hubkonen, V., Verolen, M., Pentinnen, K., Nissinen, M. & Heinonen, O. (1986). Rapid effect on endemic measles, mumps and rubella of nationwide vaccination programme in Finland. Lancet i, 137–139.CrossRefGoogle Scholar
Schenzle, D. (1984). Control of virus transmission in age-structured populations. Lecture Notes in Biomathematics 57, 171–173.CrossRefGoogle Scholar
Ueda, S., Okuno, Y., Sangkawibha, N.; Jayavasu, J., Tuchinda, D., Bukkavesa, S., Ketusingha, R. & Mansuwan, P. (1967). Studies on measles in Thailand. I. Sero-epidemiological examination. Biken Journal 10, 129–133.Google Scholar
Walsh, J. A. (1983). Selective primary health care: strategies for control of disease in the developing world. IV. Measles. Reviews of Infectious Diseases 5, 330–340.CrossRefGoogle ScholarPubMed
Yihao, Z. & Winnian, S. (1983). A review of the current impact of measles in the People's Republic of China. Reviews of Infectious Diseases 5, 411–416.CrossRefGoogle Scholar