Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-15T01:31:44.290Z Has data issue: false hasContentIssue false
  • English
  • Français

Molecular and antigenic characterization of rabies viruses from Iran identifies variants with distinct epidemiological origins

Published online by Cambridge University Press:  23 September 2003

S. A. NADIN-DAVIS ,
S. SIMANI ,
J. ARMSTRONG ,
A. FAYAZ  and
A. I. WANDELER
S. A. NADIN-DAVIS
Affiliation:
Centre of Expertise for Rabies, Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, WHO Collaborating Center for Control, Pathogenesis and Epidemiology of Rabies and OIE Reference Laboratory for Rabies, 3851 Fallowfield Road, Nepean, Ontario, Canada K2H 8P9
S. SIMANI
Affiliation:
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
J. ARMSTRONG
Affiliation:
Centre of Expertise for Rabies, Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, WHO Collaborating Center for Control, Pathogenesis and Epidemiology of Rabies and OIE Reference Laboratory for Rabies, 3851 Fallowfield Road, Nepean, Ontario, Canada K2H 8P9
A. FAYAZ
Affiliation:
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
A. I. WANDELER
Affiliation:
Centre of Expertise for Rabies, Canadian Food Inspection Agency, Ottawa Laboratory Fallowfield, WHO Collaborating Center for Control, Pathogenesis and Epidemiology of Rabies and OIE Reference Laboratory for Rabies, 3851 Fallowfield Road, Nepean, Ontario, Canada K2H 8P9
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A molecular epidemiological study of 48 recent rabies isolates recovered from cases reported throughout Iran identified three distinct viral variants, the evolutionary origins of which were identified by phylogenetic comparison with rabies viruses originating from Europe and Asia. Members of group 1 (15 isolates) were recovered from the northern half of the country only, while those of group 2 (31 isolates) were widely dispersed; both groups clustered within the widely disseminated cosmopolitan lineage. The two isolates of group 3 were detected in the northeastern tip of the country only and belonged to the Arctic strain. Rapid variant discrimination tools, employing restriction fragment length polymorphisms applied to amplified fragments of the viral genome, were devised whilst antigenic characterization of representative viruses identified a small panel of monoclonal antibodies that were also discriminatory. The future application of such methods should provide valuable epidemiological information on rabies incidence in Iran.

Type
Research Article
Information
Epidemiology & Infection , Volume 131 , Issue 1 , August 2003 , pp. 777 - 790
Copyright
© 2003 Cambridge University Press