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The neutralization of pox viruses II. Relationships betweenvaccinia, rabbitpox, cowpox and ectromelia

Published online by Cambridge University Press:  15 May 2009

T. A. McNeill
T. A. McNeill
Affiliation:
Department of Microbiology, The Queen's University of Belfast
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Plaque neutralization on HEp 2 cells was used to determine the relationship between vaccinia, rabbitpox, cowpox and ectromelia using both 7 S and 19 S antibody. It was shown that for the strains of virus used vaccinia and rabbitpox were very similar but cowpox and particularly ectromelia were clearly distinguishable. The cross-titration relationships were the same for 7 S and 19 S antibody.

The titration slopes and kinetics of cross-neutralizations were interpreted on the basis of a hypothesis of antibody competition put forward in the preceding paper. It was tentatively concluded that these four viruses share a common critical antigen for neutralization and that differences in the structure or presentation of neighbouring antigens could give rise to some of the observed effects.

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 549 - 555
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Appleyard, G. & Westwood, J. C. N. (1964). A protective antigen from the pox viruses. II. Immunization of animals. Br. J. exp. Path. 45, 162.Google ScholarPubMed
Downie, A. W. & MacDonald, A. (1950). A study of the pox viruses by complement fixation and inhibition of complement fixation methods. J. Path. Pact. 62, 389.CrossRefGoogle ScholarPubMed
Downie, A. W. & McCarthy, K. (1950). The viruses of variola, vaccinia, cowpox and ectromelia—neutralization tests on the chorioallantois with unabsorbed and absorbed immune sera. Br. J. exp. Path. 31, 789.Google ScholarPubMed
Gispen, R. (1955). Analysis of pox virus antigens by means of double diffusion. A method for direct serological differentiation of cowpox. J. Immun. 74, 134.CrossRefGoogle ScholarPubMed
Lafferty, K. J. (1963). The interaction betweenvirus and antibody. II. Mechanism of the reaction. Virology 21 76.CrossRefGoogle Scholar
MacDonald, A. & Downie, A. W. (1950). Serological study of the soluble antigens of variola, vaccinia, cowpox, and ectromelia viruses. Br. J. exp. Path. 31, 784.Google ScholarPubMed
McNeill, T. A. (1965). The antibody response ofrabbits to inactivated vaccinia virus. J. Hyg., Camb. 63, 525.Google ScholarPubMed
McNeill, T. A. (1968). The neutralization of pox viruses. I. Evidence for antibody interference. J. Hyg., Camb. 66, 541.Google Scholar