Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-14T04:19:59.421Z Has data issue: false hasContentIssue false
  • English
  • Français

On the Absorption of Antibodies from the Subcutaneous Tissues and Peritoneal Cavity

Published online by Cambridge University Press:  15 May 2009

J. Henderson Smith
J. Henderson Smith
Affiliation:
Philip Walker Student of Pathology in the University of Oxford.
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Antibodies in general are absorbed very slowly from the peritoneal cavity in lower animals, and from the subcutaneous tissues in man and animals. Absorption from the latter is not complete until at least 2—3 days have elapsed.

2. The amount of antibody present at any one time in the general circulation after intraperitoneal or subcutaneous injection is very much less than the amount injected.

3. Clinically, in urgent cases of disease, to inject antibodies subcutaneously is not only to lose 2—3 days' time before the full action can be obtained but to reduce the amount of action that the dose injected can have.

4. By intravenous injection the maximum amount of action is obtained at once.

The whole of the experiments recorded in this paper were made in the Statens Serum-Institut at Copenhagen, where every possible facility was given me for the carrying out of this research. To Dr Thorvald Madsen I desire to express my thanks not only for his unvarying kindliness and courtesy, but also for suggestions and assistance constantly given. I am pleased to have this opportunity of expressing my indebtedness to him.

Type
Research Article
Information
Journal of Hygiene , Volume 7 , Issue 2 , April 1907 , pp. 205 - 215
Copyright
Copyright © Cambridge University Press 1907

References

REFERENCES

Behring, (1897). Fortschritte der Medicin, Vol. XV. p. 1.Google Scholar
Behring, (1900). Allgemeine Therapie der Infektionskrankheiten, p. 1055.Google Scholar
Bomstein, (1897). Centralbl. f. Bakteriol., Vol. XXII. p. 587.Google Scholar
Bulloch, (1898). Durability of Passive Diphtheria Immunity. Journ. Pathol. and Bacteriol., Vol. V. p. 274.CrossRefGoogle Scholar
Dreyer, and Jex-Blake, (1906). On the agglutination of bacteria. Journ. Pathol. and Bacteriol., Vol. XI. p. 1.CrossRefGoogle Scholar
Haldane, and Smith, (1900). Journ. of Physiol., Vol. xXV. p. 341.Google Scholar
Knorr, (1900). In Behring's Allgemeine Therapie der Infektionskrankheiten, p. 1054.Google Scholar
Madsen, and Jörgensen, (1902). The fate of typhoid and cholera agglutinins during active and passive immunisation. Festskrift ved Indvielsen af Statens Serum-Institut, Paper No. VI., Copenhagen.Google Scholar
Müller, E. (1897). Jahrbuch f. Kinderheilkunde, Vol. XLIV. p. 394.Google Scholar
Pfeiffer, and Friedberger, (1904). Centralbl. f. Bakteriol., Vol. XXXVII. p. 131.Google Scholar
Ransom, (1901). Die Vertheilung von Tetanusgift u. Tetanusantitoxin im lebenden Körper. Berlin. klin. Woch., p. 337.Google Scholar
Schäfer, (1898). Text-Book of Physiology, Vol. I. p. 147.Google Scholar