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On the Bactericidal Effect exerted by Human Blood on certain species of Pathogenic Micro-Organisms and on the Antibactericidal Effects obtained by the addition to the blood in vitro of Dead Cultures of the Micro-Organisms in question

Published online by Cambridge University Press:  15 May 2009

A. E. Wright  and
F. N. Windsor
A. E. Wright
Affiliation:
Professor of Pathology, Army Medical School, Netley;
F. N. Windsor
Affiliation:
Capt., Indian Medical Service.
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The fact that the blood of ordinary laboratory animals exerts a very marked bactericidal effect upon the Bacillus typhosus and the Spirillum cholerae asiaticae, while it exerts little or no effect upon the Staphylococcus and Streptococcus pyogenes, has hardly received the attention which it would seem to merit in view of the circumstance that these facts involve the important problem as to whether the blood exerts its bactericidal action upon pathogenic organisms generally, or only upon certain species of such micro-organisms.

Type
Research Article
Information
Journal of Hygiene , Volume 2 , Issue 4 , October 1902 , pp. 385 - 413
Copyright
Copyright © Cambridge University Press 1902

References

page 385 note 1 Lancet, 06 1, 1901, p. 1532Google Scholar; Proc. Roy. Soc. (this paper is about to appear).

page 388 note 1 Data with regard to the first of these points have already been set forth by one of us in a paper published in the Lancet, Sept. 14th, 1901, p. 715, dealing with the changes produced in the blood by antityphoid inoculation. The second of these questions has also been briefly adverted to in the same Journal, June 1st, 1901, p. 1534, in connection with a suggestion that the antibactericidal effect exerted might serve as a criterion for the standardization of bacterial vaccines.

page 394 note 1 Wright, , Lancet, 09. 14, 1901, p. 715.CrossRefGoogle Scholar

page 394 note 2 The circumstance that a positive phase of increased bactericidal power was obtained in case of the typhoid rabbit without the intervention of a negative phase of diminished bactericidal power is in accordance with what occurs in man after the inoculation of a relatively small dose of typhoid vaccine (Wright, Lancet, Sept. 14, 1901, p. 715).

page 397 note 1 Zeitschrift f. Hygiene, 1888, vol. IV. pp. 353–394.Google Scholar

page 397 note 2 The technique employed in connection with the observations here in question was that which was described by one of us in the Lancet, Dec. 1, 1900, pp. 1556–1560.