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On the Relation of the Antitoxin to the Globulin-Content of the Blood Serum during Diphtheria Immunisation

Published online by Cambridge University Press:  15 May 2009

J. C. G. Ledingham
J. C. G. Ledingham
Affiliation:
Assistant Bacteriologist, Lister Institute of Preventive Medicine.
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1. During the immunisation of a horse which ultimately failed to yield high grade antitoxic serum, the globulin-content of the total proteid showed no tendency to increase. The slight rise in total proteid which occurred was due to an increase in the albumin fraction. It is probable that the failure of this horse to yield high grade antitoxin was in some way connected with the initial high globulin-content of the serum.

2. During the immunisation of a goat, the rise in total proteid affected mainly the albumin fraction and the globulin fraction in lesser degree.

3. During the immunisation of a horse which ultimately yielded high grade antitoxic serum, the percentage globulin-content of the total proteid, progressively increased. This increase affected the euglobulin fraction more than the pseudoglobulin fraction.

4. In the horse the pseudoglobulin contains the greater part if not all the antitoxin but it seems probable that this relationship holds good only when the antitoxin-content of the serum is steadily rising.

5. In the goat the antitoxin-content of the euglobulin and pseudoglobulin fractions may vary at different periods in the course of immunisation.

Type
Research Article
Information
Journal of Hygiene , Volume 7 , Issue 1 , January 1907 , pp. 65 - 91
Copyright
Copyright © Cambridge University Press 1907

References

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