Hostname: page-component-745bb68f8f-grxwn Total loading time: 0 Render date: 2025-02-04T17:36:30.605Z Has data issue: false hasContentIssue false
  • English
  • Français

Predictors for the development of haemolytic uraemic syndrome with Escherichia coli O157[ratio ]H7 infections: with focus on the day of illness

Published online by Cambridge University Press:  01 June 2000

K. IKEDA ,
O. IDA ,
K. KIMOTO ,
T. TAKATORIGE ,
N. NAKANISHI  and
K. TATARA
K. IKEDA
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
O. IDA
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
K. KIMOTO
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
T. TAKATORIGE
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
N. NAKANISHI
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
K. TATARA
Affiliation:
Osaka University, Graduate School of Medicine, Course of Social Medicine, Department of Social and Environmental Medicine, 2-2, Yamadaoka, Suita-City, Osaka 565-0871, Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A large outbreak of Escherichia coli O157 infections via school lunches occurred at primary schools in 1996 in Sakai City, Japan. As many as 10000 patients suffered from diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome (HUS). Using data on 288 inpatient school children affected by this outbreak, of whom 36 presented complete HUS and the remaining 252 tested positive for E. coli O157 culture, we attempted to identify predictors for the progression to HUS. Within the first 5 days of illness, clinical features associated with inpatients who developed HUS compared with those without HUS included a C reactive protein (CRP) level higher than 1·2 mg/dl (OR 44·26; 95% CI 5·83–336·23), a white blood cell (WBC) count greater than 11·0 × 109/1 (OR 5·03; 95% CI 27·13–11·87) and a temperature higher than 38·0 °C (OR 5·00; 95% CI 2·25–117·08). It can be concluded that these three factors are predictive factors for the development of HUS in patients with E. coli O157 infection, and patients who have two or all of these factors should be observed closely.

Type
Research Article
Information
Epidemiology & Infection , Volume 124 , Issue 3 , June 2000 , pp. 343 - 349
Copyright
© 2000 Cambridge University Press