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Prospective study of the incidence of diarrhoea and prevalence of bacterial pathogens in a cohort of Vietnamese children along the Red River

Published online by Cambridge University Press:  26 November 2001

D. W. ISENBARGER ,
B. T. HIEN ,
H. T. HA ,
T. T. HA ,
L. BODHIDATTA ,
L. W. PANG  and
P. D. CAM
D. W. ISENBARGER
Affiliation:
Armed Forces Research Institute of Medical Science, Department of Enteric Diseases, Bangkok, Thailand Walter Reed Army Institute of Research, Department of Enteric Infections, Washington, DC, USA
B. T. HIEN
Affiliation:
National Institute of Hygiene and Epidemiology, Department of Microbiology, Hanoi, Vietnam
H. T. HA
Affiliation:
National Institute of Hygiene and Epidemiology, Department of Microbiology, Hanoi, Vietnam
T. T. HA
Affiliation:
National Institute of Hygiene and Epidemiology, Department of Microbiology, Hanoi, Vietnam
L. BODHIDATTA
Affiliation:
Armed Forces Research Institute of Medical Science, Department of Enteric Diseases, Bangkok, Thailand
L. W. PANG
Affiliation:
Armed Forces Research Institute of Medical Science, Department of Enteric Diseases, Bangkok, Thailand
P. D. CAM
Affiliation:
National Institute of Hygiene and Epidemiology, Department of Microbiology, Hanoi, Vietnam
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Abstract

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We prospectively studied diarrhoea incidence among 1655 children < 5 years of age in northern Vietnam for 1 year using primarily passive surveillance. Standard culture methods were used to detect bacterial pathogens. Overall 2160 cases occurred (1·3 cases/child per year). Peak rates of diarrhoea occurred in children < 12 months old. Rates ranged from 3·3 cases/child per year in children < 1 year old, to 0·7 cases/child per year in 4-year-olds. Campylobacter, shigella and enterotoxigenic Escherichia coli were most commonly isolated. Rates detected by active surveillance were about twice those detected passively. S. flexneri was the most common shigella serogroup (65%). S. flexneri serotypes 6, 4, 1 and Y were most common, but 40% were untypable using commercial antisera. The data illustrate important regional differences in pathogen prevalence and shigella serotype distribution. Shigella vaccine development strategies, commonly targeting S. flexneri 2a, S. sonnei and S. dysenteriae 1, will have little impact on diarrhoea rates in Vietnam.

Type
Research Article
Information
Epidemiology & Infection , Volume 127 , Issue 2 , October 2001 , pp. 229 - 236
Copyright
2001 Cambridge University Press