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The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams

Published online by Cambridge University Press:  19 October 2009

J. M. Dolby  and
D. G. Newell
J. M. Dolby
Affiliation:
Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, UK
D. G. Newell
Affiliation:
Public Health Service Laboratory, Southampton General Hospital, Southampton S09 4XY, UK
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Summary

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Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 °C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4–6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 °C destroyed its protective properties. A vaccine prepared from an anagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young.

Type
Research Article
Information
Journal of Hygiene , Volume 96 , Issue 2 , April 1986 , pp. 143 - 151
Copyright
Copyright © Cambridge University Press 1986

References

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