The relationships of chronic hepatitis and cirrhosis to alcohol intake, hepatitis B and C, and delta virus infection: a case-control study in Albania

L. A. KONDILI; M. E. TOSTI; M. SZKLO; A. COSTANTINO; R. COTICHINI; B. RESULI; M. RAPICETTA; A. MELE

doi:10.1017/S0950268898001216

Abstract

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The present study examined the effect of hepatitis B virus (HBV) and alcohol intake, and the role of hepatitis delta virus (HDV) and hepatitis C virus (HCV) in the aetiology of chronic liver disease in Albania. A total of 106 cases of liver cirrhosis or chronic hepatitis were compared to 195 control patients without these or other liver diseases. Adjusted odds ratios were 52·7 (95% CI 22·7–122) for HBV surface antigen, 26·9 (95% CI 4·9–147) for anti-HCV, 26·2 (95% CI 3·1–221) for anti-HDV, 2.4 (95% CI 1·3–4·4) for lifetime alcohol intake and 2·3 (95% CI 1–5·5) for duration of alcohol intake. Although not significant, an interaction was suggested between HBsAg and anti-HCV and between HBsAg and alcohol intake. Our study underlines the role of hepatitis viruses in the development of chronic liver diseases. Additionally, it suggests that heavy alcohol intake may magnify the effect of HBV on these diseases. HBV vaccination and alcohol abstention appear to be important strategies to reduce the risk of liver cirrhosis and chronic hepatitis in Albania.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Everhart, James and Herion, David 2000. Hepatitis C. Vol. 2, Issue. , p. 363.

Gao, Bin 2002. Interaction of alcohol and hepatitis viral proteins. Alcohol, Vol. 27, Issue. 1, p. 69.

Tsai, Jung-Fa Jeng, Jen-Eing Chuang, Lee-Yea Ho, Mei-Shang Ko, Yin-Chin Lin, Zu-Yau Hsieh, Min-Yuh Chen, Shin-Chern Chuang, Wan-Lung Wang, Liang-Yen Yu, Ming-Lung Dai, Chia-Yen and Ho, Chen 2003. Habitual Betel Quid Chewing as a Risk Factor for Cirrhosis. Medicine, Vol. 82, Issue. 5, p. 365.

Balasubramanian, Sripriya and Kowdley, Kris V. 2005. Effect of Alcohol on Viral Hepatitis and Other Forms of Liver Dysfunction. Clinics in Liver Disease, Vol. 9, Issue. 1, p. 83.

Kondili, Loreta A. Taliani, Gloria Cerga, Gojart Tosti, Maria E. Babameto, Adriana and Resuli, Bashkim 2005. Correlation of alcohol consumption with liver histological features in non-cirrhotic patients. European Journal of Gastroenterology & Hepatology, Vol. 17, Issue. 2, p. 155.

Kondili, L.A. Brunetto, M.R. Maina, A.M. Argentini, C. Chionne, P. La Sorsa, V. Resuli, B. Mele, A. and Rapicetta, Maria 2005. Clinical and molecular characterization of chronic hepatitis B in Albania: A country that is still highly endemic for HBV infection. Journal of Medical Virology, Vol. 75, Issue. 1, p. 20.

Perz, Joseph F. Armstrong, Gregory L. Farrington, Leigh A. Hutin, Yvan J.F. and Bell, Beth P. 2006. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. Journal of Hepatology, Vol. 45, Issue. 4, p. 529.

KONDILI, L. A. CHIONNE, P. PORCARO, A. MADONNA, E. TAFFON, S. RESULI, B. TALIANI, G. and RAPICETTA, M. 2006. Seroprevalence of hepatitis E virus (HEV) antibody and the possible association with chronic liver disease: a case-control study in Albania. Epidemiology and Infection, Vol. 134, Issue. 1, p. 95.

Katsanos, Konstantinos H. Christodoulou, Dimitrios K. Zervou, Eleftheria Babameto, Adriana Craja, Blendar Hyphantis, Heleni Karetsos, Vasileios Tsonis, Gerasimos Basho, Jovan Resuli, Bashkim F. and Tsianos, Epameinondas V. 2009. Hepatitis B remains a major health priority in Western Balkans: Results of a 4-year prospective Greek–Albanian collaborative study. European Journal of Internal Medicine, Vol. 20, Issue. 7, p. 698.

Gitto, S. Micco, L. Conti, F. Andreone, P. and Bernardi, M. 2009. Alcohol and viral hepatitis: A mini-review. Digestive and Liver Disease, Vol. 41, Issue. 1, p. 67.

Kondili, Loreta A. Çuko, Liri Chionne, Paola Candido, Angela Madonna, Elisabetta Dentico, Pietro Resuli, Bashkim Taliani, Gloria Brunetto, Maurizia R. and Rapicetta, Maria 2010. Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years. European Journal of Gastroenterology & Hepatology, Vol. 22, Issue. 2, p. 167.

Mota, Ana Guedes, Fátima Areias, Jorge Pinho, Luciana and Cardoso, Margarida Fonseca 2010. Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences. Alcohol, Vol. 44, Issue. 2, p. 149.

Min, Bo Young Kim, Nam Young Jang, Eun Sun Shin, Cheol Min Lee, Sang Hyup Park, Young Soo Hwang, Jin-Hyeok Jeong, Sook-Hyang Kim, Nayoung Lee, Dong Ho and Kim, Jin-Wook 2013. Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation. Biochemical and Biophysical Research Communications, Vol. 431, Issue. 1, p. 92.

Taylor Richardson, C. and Singal, Ashwani K. 2019. Clinical Epidemiology of Chronic Liver Diseases. p. 75.

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The relationships of chronic hepatitis and cirrhosis to alcohol intake, hepatitis B and C, and delta virus infection: a case-control study in Albania

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