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The response to oral poliovaccine in persons aged 16–18 years

Published online by Cambridge University Press:  15 May 2009

J. W. G. Smith ,
J. A. Lee ,
W. B. Fletcher ,
C. A. Morris ,
D. A. Parker ,
Risha Yetts ,
D. I. Magrath  and
F. T. Perkins
J. W. G. Smith
Affiliation:
Epidemiological Research Laboratory, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
J. A. Lee
Affiliation:
Epidemiological Research Laboratory, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
W. B. Fletcher
Affiliation:
Epidemiological Research Laboratory, Central Public Health Laboratory, Colindale Avenue, London NW9 5HT
C. A. Morris
Affiliation:
Public Health Laboratory, Shrewsbury
D. A. Parker
Affiliation:
Public Health Laboratory, Shrewsbury
Risha Yetts
Affiliation:
National Institute for Biological Standards and Control, Hampstead, London NW3 6RB
D. I. Magrath
Affiliation:
National Institute for Biological Standards and Control, Hampstead, London NW3 6RB
F. T. Perkins
Affiliation:
National Institute for Biological Standards and Control, Hampstead, London NW3 6RB
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Summary

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Serum neutralizing antibodies to polioviruses were titrated in serum samples from 182 police cadets aged 16–18 years before and, in 168 of the cadets, 6 weeks after vaccination with a single dose of oral polio vaccine (OPV). Faecal excretion of poliovirus was also followed. Vaccination histories were obtained and confirmed whenever possible.

Pre-vaccination antibody could not be detected against type 1 in 9·3% cadets, against type 2 in 2·7% and against type 3 in 7·7%. Absence of antibody to at least one virus type was found in 14·3 % of the cadets.

In 93 cadets in whom vaccination histories could be confirmed 40 had received only inactivated polio vaccine (IPV) previously; of these 23% lacked antibody to at least one virus type, and they had less intestinal immunity to a challenge dose of OPV than those previously given OPV. Only two of the cadets known to have had OPV were non-immune – both had received a single dose following full courses of IPV. However, cadets who had received OPV had their last dose of vaccine more recently (average 4.6 years) than those who had received only IPV (all 12 years or more).

The serum antibody response to a single booster dose of OPV, and the faecal excretion of each type of virus after vaccination, showed an inverse relation to the corresponding pre-vaccination antibody concentration. A single dose of OPV did not reliably boost the immunity of those who possessed adequate immunity, and a failure to respond was also observed in a proportion of the cadets with no detectable antibody, mostly in the case of type 3 antibody and particularly if antibody to types 1 or 2 virus was also absent. No evidence was obtained that intestinal immunity could be expected in the absence of detectable circulating antibody.

The reasons for the absence of a serological response to OPV in some subjects are discussed and consideration is given to the practical significance of the findings. It is suggested that reinforcement of polio immunity at school-leaving is important, particularly at the present time when many of those aged 16–18 years will have been vaccinated only with IPV. A single does of OPV is not ideal for this purpose, not only because a small proportion of persons are liable to be left unprotected, but also because failure to produce a reliable boost in persons with adequate immunity at the time of vaccination gives rise to the possibility that they may become susceptible later in adult life.

Type
Research Article
Information
Journal of Hygiene , Volume 76 , Issue 2 , April 1976 , pp. 235 - 247
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Beale, A. J., Davies, J. R. & Thrower, A. L. (1965). Response to one dose of trivalent oral poliovaceine in children previously immunized with Salk vaccine. Lancet i, 879.CrossRefGoogle Scholar
D.H.S.S. (1972 a). On the state of the Public Health. The Annual Report of the Chief Medical Officer of the Department of Health and Social Security for the year 1971. London: H.M.S.O.Google Scholar
D.H.S.S. (1972 b). Immunisation against infectious disease. Department of Health and Social Security, July 1972.Google Scholar
Galbraith, N. S. & Fernandes, R. (1969). Polioantibody titres in children aged 7–15 years in London. Lancet ii, 792.CrossRefGoogle Scholar
Glezen, W. P., McCollough, R. H., Lamb, G. A. & Chin, T. D. Y. (1969). Quantitative relationship of pre-existing homotypic antibodies to excretion of poliovirus types 1, 2 and 3 following the feeding of trivalent attenuated poliovirus vaccine. American Journal of Epidemiology 90, 146.CrossRefGoogle Scholar
Henry, J. L., Jaikaran, E. S., Davies, J. R., Tomlinson, A. J. H., Mason, P. J., Barnes, J. M. & Beale, A. J. (1966). A study of poliovaccination in infancy: excretion following challenge with live virus by children given killed or living poliovaccine. Journal of Hygiene 64, 105.CrossRefGoogle ScholarPubMed
McCollough, R. H., Glezen, W. P., Lamb, G. A. & Ohin, T. D. Y. (1969). Booster effect of oral poliovaccine. Trials in persons previously immunized with inactivated vaccine. American Journal of Diseases of Children 117, 161.CrossRefGoogle ScholarPubMed
Mair, H. J. & Tobin, J. O'H. (1960). Some observations on the use of secondary monkey cell cultures for the routine diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 19, 49.Google ScholarPubMed
Miller, D. L., Reid, D. & Diamond, J. R. (1970). Poliomyelitis surveillance in England and Wales, 1965–8. Public Health, London 84, 265.CrossRefGoogle ScholarPubMed
Mortimer, P. P. & Cunningham, P. (1975). Sero-immunity to poliovirus in children and young women: England 1972–4. Journal of Hygiene 74, 283.CrossRefGoogle Scholar
Murphy, A. M., Hardie, A., Stout, M., Field, P. R. & James, B. R. (1972). The current state of immunity to polioviruses in New South Wales. Medical Journal of Australia ii, 1404.CrossRefGoogle Scholar
Perkins, F. T. & Evans, D. G. (1959). British standard poliomyelitis antisera types 1, 2 and 3. British Medical Journal i, 1549.CrossRefGoogle Scholar
P.H.L.S. (1973). Poliomyelitis in 1972. British Medical Journal iii, 57.Google Scholar
P.H.L.S. (1974). Poliomyelitis in England and Wales. British Medical Journal iii, 585.Google Scholar
Rasmussen, C. M., Thomas, C. W., Mulrooney, R. J. & Morrissey, R. A. (1973). Inadequate poliovirus immunity levels in immunized Illinois children. American Journal of Diseases of Children 126, 465.Google ScholarPubMed
Reid, D., Bell, E. J., Grist, N. R. & Wilson, T. S. (1973). Poliomyelitis: a gap in immunity? Lancet ii, 899.CrossRefGoogle Scholar
Reid, D., Yetts, R., Oddy, C. G. & Benson, P. F. (1969). Poliomyelitis antibody titres in children and effect of live and inactivated poliovaccine. Lancet i, 564.CrossRefGoogle Scholar
Skelton, J., Schild, G. C. & Stuart-Harris, C. H. (1966). Screening of children's sera for antibodies to polioviruses. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 25, 191.Google ScholarPubMed