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Role of rubella in congenital malformations in India

Published online by Cambridge University Press:  15 May 2009

U. C. Chaturvedi
Affiliation:
Department of Pathology and Bacteriology, K.G. Medical College, Lucknow, India
B. N. Tripathi
Affiliation:
Department of Pathology and Bacteriology, K.G. Medical College, Lucknow, India
Asha Mathur
Affiliation:
Department of Pathology and Bacteriology, K.G. Medical College, Lucknow, India
U. K. Singh
Affiliation:
Department of Pathology and Bacteriology, K.G. Medical College, Lucknow, India
R. M. L. Mehrotra
Affiliation:
Department of Pathology and Bacteriology, K.G. Medical College, Lucknow, India
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In the present study rubella HI antibodies were determined in cases of congenital malformation and bad obstetric history to determine the role of rubella in such cases in India, as it has been reported to be rare in Japan in contrast to Western countries. The incidence of antibodies was statistically significant in cases of congenital eye, c.n.s., visceral and miscellaneous malformations and cases of spontaneous abortion and still-birth compared with controls of matching age groups. This is further supported by the demonstration of IgM antibodies in seven cases of congenital malformations and ten cases of spontaneous abortion. Our findings show that congenital rubella is not rare in India.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Banatvala, J. E., Best, J. M., Kennedy, E. A., Smith, E. A. & Spence, M. E. (1967). A serological method for demonstrating recent infection by rubella virus. British Medical Journal iii, 285–6.CrossRefGoogle Scholar
Best, J. M., Banatvala, J. E. & Bowen, J. M. (1974). New Japanese rubella vaccine: Comparative trials. British Medical Journal iii, 221–4.CrossRefGoogle Scholar
Best, J. M., Banatvala, J. E. & Watson, D. (1969). Serum IgM and IgG responses in postnatally acquired rubella. Lancet ii, 65–8.CrossRefGoogle Scholar
Coopeb, L. Z. & Kbugman, S. (1966). Diagnosis and management of congenital rubella. Pediatrics 37, 335–8.Google Scholar
Dudgeon, J. A. (1967). Maternal rubella and its effect on the foetus. Archives of Disease in Childhood 42, 110–25.CrossRefGoogle ScholarPubMed
Gtjmpel, S. M., Hayes, K. & Dudgeon, J. A. (1971). Congenital perceptive deafness: Role of intrauterine rubella. British Medical Journal ii, 300–4.Google Scholar
Halonen, P. E.Ryan, J. H. & Stewart, J. A. (1967). Rubella haemagglutinin prepared with alkaline extraction of virus grown in suspension culture of BHK-21 cells. Proceedings of the Society for Experimental Biology and Medicine 125, 162–7.CrossRefGoogle ScholarPubMed
Honeyman, M. C. & Menseb, M. A. (1974). Ethnicity is a significant factor in the epidemiology of rubella and Hodgkin's disease. Nature, London 251, 441–2.CrossRefGoogle ScholarPubMed
Kono, R., Hayakawa, Y., Hibi, M. & Ishii, K. (1969). Experimental vertical transmission of rubella virus in rabbits. Lancet i, 343–5.CrossRefGoogle Scholar
Mathub, A., Chatubvedi, U. C. & Mehrotra, R. M. L. (1974). Serological study for the prevalence of rubella at Lucknow. Indian Journal of Medical Research 62, 307–10.Google Scholar
Potter, J. E., Banatvala, J. E. & Best, J. M. (1973). Interferon studies with Japanese and U.S. rubella virus strains. British Medical Journal i, 197–9.CrossRefGoogle Scholar
Rawls, W. E., Melnick, J. L., Bradstbeet, C. M. P., Bailey, M., Fekris, A. A., Lehmann, N. I., Nagleb, F. P., Furesz, J., Kono, R., Ohtawara, M., Halonen, P., Stewart, J., Ryan, J. M., Strauss, J., Zdrazilek, I., Leerhoy, J., Von Magnus, H., Sohieb, R. & Febreira, W. (1967). WHO collaborative study on seroepidemiology of rubella. Bulletin of the World Health Organization 37, 7988.Google Scholar