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Salivary excretion of rabies virus by healthy vampire bats

Published online by Cambridge University Press:  07 February 2005

A. AGUILAR-SETIEN ,
E. LOZA-RUBIO ,
M. SALAS-ROJAS ,
N. BRISSEAU ,
F. CLIQUET ,
P.-P. PASTORET ,
S. ROJAS-DOTOR ,
E. TESORO  and
R. KRETSCHMER
A. AGUILAR-SETIEN
Affiliation:
Unidad de Investigación Médica en Inmunología, Coordinación de Investigación Médica, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, México D.F., Mexico
E. LOZA-RUBIO
Affiliation:
Centro Nacional de Investigaciones Disciplinarias en Microbiología, Instituto Nacional de Investigaciones Forestales y Agropecuarias, México D.F., Mexico
M. SALAS-ROJAS
Affiliation:
Unidad de Investigación Médica en Inmunología, Coordinación de Investigación Médica, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, México D.F., Mexico
N. BRISSEAU
Affiliation:
Laboratoire d’études et de recherches sur la rage et la pathologie des animaux sauvages, Domaine de Pixérécourt, Malzeville, France
F. CLIQUET
Affiliation:
Laboratoire d’études et de recherches sur la rage et la pathologie des animaux sauvages, Domaine de Pixérécourt, Malzeville, France
P.-P. PASTORET
Affiliation:
Institute for Animal Health, Compton Newbury, Berks, UK
S. ROJAS-DOTOR
Affiliation:
Unidad de Investigación Médica en Inmunología, Coordinación de Investigación Médica, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, México D.F., Mexico
E. TESORO
Affiliation:
Departamento de Investigación Experimental y Bioterio del Instituto Nacional de Ciencias Médicas y Nutrición ‘Salvador Zubirán’, México D.F., Mexico
R. KRETSCHMER
Affiliation:
Unidad de Investigación Médica en Inmunología, Coordinación de Investigación Médica, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Pediatría, México D.F., Mexico
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Abstract

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Salivary excretion of rabies virus was evaluated in 14 adult vampire bats (Desmodus rotundus) intramuscularly injected with a large dose (106 MICLD50) of vampire rabies virus variant CASS88. Saliva samples were obtained from surviving bats every other day for 30 days, then weekly for 2 months, and finally 1 and 2 years later. Rabies virus was isolated in murine neuroblastoma cells and in randomly selected cases by PCR. Rabies virus was not detected in the saliva of any of the 11 animals that succumbed (somewhat early) to rabies challenge, nor in the control bats. In contrast, virus was detected early, and only once (days 6, 6 and 21) in each of the three animals that survived rabies challenge and remained healthy for at least 2 years after challenge. At that time even vigorous dexamethasone and cyclosporine administration failed to provoke further viral excretion.

Type
Research Article
Information
Epidemiology & Infection , Volume 133 , Issue 3 , June 2005 , pp. 517 - 522
Copyright
© 2005 Cambridge University Press