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Seroprevalence of measles, mumps and rubella antibodies in Luxembourg: results from a national cross-sectional study

Published online by Cambridge University Press:  27 January 2004

J. MOSSONG ,
L. PUTZ  and
F. SCHNEIDER
J. MOSSONG
Affiliation:
Laboratoire National de Santé, PO Box 1102, L-1011 Luxembourg Centre de Recherche Public–Santé, 18 rue Dicks, L-1417 Luxembourg
L. PUTZ
Affiliation:
Laboratoire National de Santé, PO Box 1102, L-1011 Luxembourg Centre de Recherche Public–Santé, 18 rue Dicks, L-1417 Luxembourg
F. SCHNEIDER
Affiliation:
Laboratoire National de Santé, PO Box 1102, L-1011 Luxembourg
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Abstract

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A serological prevalence survey was carried out in Luxembourg during 2000–2001 to determine the antibody status of the Luxembourg population against vaccine-preventable infections. Blood samples of children and adolescents were collected prospectively in randomly selected schools. Samples of adults were obtained through volunteer patients of the national health laboratory or of the mandatory pre-nuptial test. Measles, mumps and rubella (MMR) virus antibody concentrations were measured using commercial ELISA tests. Age-standardized prevalence of measles, mumps and rubella virus antibodies was found to be 96·58, 75·40 and 95·69% respectively. Significant age-dependence of serology was observed for all three infections, with study participants born after the introduction of the MMR vaccine experiencing a gradual decline of antibodies following vaccination in childhood. Older study participants who were more likely to have antibodies from natural infection had consistently higher titres than younger individuals. Present vaccination coverage with MMR appears to be sufficient to prevent large local outbreaks of measles and rubella, but probably not mumps.

Type
Research Article
Information
Epidemiology & Infection , Volume 132 , Issue 1 , February 2004 , pp. 11 - 18
Copyright
© 2004 Cambridge University Press