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Simultaneous active and passive immunization of guinea-pigs against tetanus*

Published online by Cambridge University Press:  15 May 2009

J. W. G. Smith
J. W. G. Smith
Affiliation:
London School of Hygiene and Tropical Medicine
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1. Simultaneous active and passive immunization of guinea-pigs using tetanus toxoid adsorbed on to aluminium hydroxide produced a higher antitoxin response than simultaneous immunization using plain toxoid. The response was also better than that produced by plain toxoid alone.

2. A 24 hr. interval between the injection of plain toxoid and the subsequent injection of antitoxin gave no better results than when toxoid and antitoxin were given at the same time.

3. The response to simultaneous immunization, using adsorbed toxoid, of guinea-pigs sensitized to horse serum, was superior in the first 6 weeks to that of guinea-pigs which had not been sensitized.

4. The suggestion that simultaneous active and passive immunization of man should be performed with adsorbed toxoid rather than plain toxoid is supported by these results.

Type
Research Article
Information
Journal of Hygiene , Volume 62 , Issue 3 , September 1964 , pp. 379 - 388
Copyright
Copyright © Cambridge University Press 1964

References

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