Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-14T04:21:19.119Z Has data issue: false hasContentIssue false
  • English
  • Français

Statistical analysis of data bearing on the number of particles required to form a plaque

Published online by Cambridge University Press:  15 May 2009

J. G. Kalbfleisch  and
D. A. Sprott
J. G. Kalbfleisch
Affiliation:
University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
D. A. Sprott
Affiliation:
University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Methods of statistical analysis are presented for one or more dilution series experiments where the quantity of interest is the number of virus particles required to infect a cell. These methods are illustrated on several data sets drawn from the literature. Data from seven series, which have been used to support a two-particle model in the literature, are here shown to reject such a model decisively, whereas fifteen other experiments are found to be in excellent agreement with a one-particle model.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 1 , August 1974 , pp. 27 - 34
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Alling, D. W. (1971). Estimation of hit number. Biometrics 27, 605–13.CrossRefGoogle ScholarPubMed
Boeyé, A., Melnick, J. L. & Rapp, F. (1966). SV 40-adenovirus hybrids; presence of two genotypes and the requirement of their complementation for viral replication. Virology 28, 56–70.CrossRefGoogle Scholar
Cooper, P. D. (1961). The plaque assay of animal viruses. Advances in Virus Research 8, 319–78.CrossRefGoogle ScholarPubMed
De Maeyer, E. (1960). Plaque formation by Measles Virus. Virology 11, 634–8.CrossRefGoogle ScholarPubMed
Dulbecco, R. (1952). Production of plaques in monolayer tissue cultures by single particles of an animal virus. Proceedings of the National Academy of Sciences, U.S.A. 38, 747–52.CrossRefGoogle ScholarPubMed
Dulbecco, R. & Vogt, M. (1954). Plaque formation and isolation of pure lines with Poliomyelitis viruses. Journal of Experimental Medicine 99, 167–82.CrossRefGoogle ScholarPubMed
Finney, D. J. (1964). Statistical Method in Biological Assay, 2nd edition.London: Griffin.Google Scholar
Fisher, R. A. (1970). Statistical Methods for Research Workers, 14th edition.Edinburgh: Oliver and Boyd.Google Scholar
Kalbfleisch, J. G. & Sprott, D. A. (1974). Inferences about hit number in a virological model. Biometrics 30, 199–208.CrossRefGoogle Scholar
Kempthorne, O. (1969). An Introduction to Genetic Statistics. Ames, Iowa: State University Press.Google Scholar
Khera, K. S. & Maurin, J. (1958). L'etude par la methode des plaques du virus aphteux (type C) en couche monocellulaire de rein de porcelet. Annales de l'institut Pasteur 95, 557–67.Google Scholar
Kjellén, L. (1961). A study of adenovirus in host cell systems by the plaque technique. Virology 14, 234–9.CrossRefGoogle Scholar
Reid, D. B. W., Crawley, J. F. & Rhodes, A. (1949). A study of fowl pox virus detection on the chorioallantois by the poch counting technique. Journal of Immunology 63, 165–71.CrossRefGoogle Scholar