Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-15T01:31:56.619Z Has data issue: false hasContentIssue false

A survey of measles antibodies in different populations

Published online by Cambridge University Press:  15 May 2009

Gillian Tilden Smith
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory, Colindale, London, N.W. 9
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A survey of serum samples from all age groups in the population has shown a rapid acquisition of antibody between the ages of 1 and 6 years which reaches a plateau in concentration and does not disappear later.

The concentration of antibody in cord serum may be four or more times greater than that in the mother's serum.

Presence or absence of a record of past infection by measles is not necessarily reflected by the titre of antibody in the serum.

Low antibody titres in very young infants may be due to an imperfectly developed antibody producing mechanism.

The author gratefully acknowledges the assistance of all those who made this survey possible. In particular, she is indebted to Dr G. I. Watson of the College of General Practitioners and his colleagues (see list) for their help in the collection of so many of the serum samples, and to Mr D. A. Bamgboye for his excellent technical assistance.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1964

References

REFERENCES

Bech, V. (1960). Titres of complement fixing measles antibodies in human sera collected from one to five years after illness. Acta path. microbiol. scand. 50, 81.CrossRefGoogle ScholarPubMed
Black, F. L. (1959). Measles antibodies in the population of New Haven, Connecticut. J. Immunol. 83, 74.CrossRefGoogle ScholarPubMed
Black, F. L. (1962). Measles antibody prevalence in diverse populations. Amer. J. Dis. Child. 103, 242.Google ScholarPubMed
Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement-fixation test applicable to the diagnosis of virus diseases. Mon. Bull. Minist. Hlth Lab. Serv. 21, 96.Google Scholar
Langmuir, A. D. (1962). Medical importance of measles. Amer. J. Dis. Child. 103, 224.Google ScholarPubMed
Morgan, J. F., Morton, H. J. & Parker, R. C. (1950). Nutrition of animal cells in tissue culture. 1. Initial studies on a synthetic medium. Proc. Soc. exp. Biol., N.Y. 73, 1.CrossRefGoogle ScholarPubMed
Oberman, J. W., Gregory, K. O., Burke, F. G., Ross, S. & Rice, E. C. (1956). Electrophoretic analysis of serum proteins in infants and children. 1. Normal values from birth to adolescence. New Engl. J. Med. 255, 743.CrossRefGoogle Scholar
Reed, L. J. & Muench, H. (1938). A simple method of estimating 50 per cent endpoints. Amer. J. Hyg. 27, 493.Google Scholar
Report (1961). Trial of living attenuated poliovirus vaccine. A report of the Public Health Laboratory Service to the Poliomyelitis Vaccines Committee of the Medical Research Council. Brit. med. J. ii, 1037.Google Scholar
Ruckle, G. & Rogers, K. D. (1957). Studies with measles virus. II. Isolation of virus and immunologic studies in persons who have had the natural disease. J. Immunol. 78, 341.CrossRefGoogle ScholarPubMed
Snyder, M. J., McCrumb, F. R. Jr., Bigbee, T., Schluederberg, A. E. & Togo, Y. (1962). Observations on the seroepidemiology of measles. Amer. J. Dis. Child. 103, 250.Google ScholarPubMed