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The Toxicity to Animals of 1:4 Dioxan

Published online by Cambridge University Press:  15 May 2009

A. Fairley ,
E. C. Linton  and
A. H. Ford-Moore
A. Fairley
Affiliation:
From the Government Experimental Establishment at Porton, Wiltshire
E. C. Linton
Affiliation:
From the Government Experimental Establishment at Porton, Wiltshire
A. H. Ford-Moore
Affiliation:
From the Government Experimental Establishment at Porton, Wiltshire
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Rabbit 1 and mouse 1 probably died from pneumonia, although, both animals showed well-marked lesions in both liver and kidneys. The rat lungs were—as usual—dubious. In the other animals the lungs were normal and the picture was one of hepatic and renal damage alone.

At this concentration, the likelihood of pulmonary affections, and death therefrom, appears to be much less than in the cases of animals exposed to 1/100.

Pulmonary inflammation does not occur at this concentration, and the lesions were exclusively hepatic and renal.

Summary.Pulmonary inflammation does not occur at this concentration, and the lesions were exclusively hepatic and renal.

Summary. The rats in the experiment seemed to be more severely affected than the mice, and two rats died with an acute enteritis. The renal and hepatic tissue changes were also more severe in the rats.

Type
Research Article
Information
Journal of Hygiene , Volume 34 , Issue 4 , December 1934 , pp. 486 - 501
Copyright
Copyright © Cambridge University Press 1934

References

REFERENCES

Van Oettingen, W. F. and Jirouch, E. A. (1931). J. Pharmacol. and Exp. Therap. 42, 355.Google Scholar
Yant, W. P., Schrenk, H. H., Waite, C. P. and Patty, F. A. (1930). Public Health Report (U.S. Pub. Health Service), 45, 35, 2023—2032.Google Scholar