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The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines

Published online by Cambridge University Press:  15 May 2009

F. Brown ,
N. St G. Hyslop ,
Joan Crick  and
A. W. Morrow
F. Brown
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
N. St G. Hyslop
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
Joan Crick
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
A. W. Morrow
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
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Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr.

Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.

Type
Research Article
Information
Journal of Hygiene , Volume 61 , Issue 3 , September 1963 , pp. 337 - 344
Copyright
Copyright © Cambridge University Press 1963

References

REFERENCES

Brown, F. & Crick, J. (1959). Application of agar-gel diffusion analysis to a study of the antigenic structure of inactivated vaccines prepared from the virus of foot-and-mouth disease. J. Immunol. 8, 444.CrossRefGoogle Scholar
Frenkel, H. S. (1951). Research on foot-and-mouth disease. III. The cultivation of the virus on a practical scale in explanations of bovine tongue epithelium. Amer. J. vet. Res. 12, 187.Google Scholar
Henderson, W. M. (1952). Significance of tests for non-infectivity of foot-and-mouth disease vaccines. J. Hyg., Camb., 50, 195.CrossRefGoogle ScholarPubMed
Martin, W. B. & Chapman, W. G. (1961). The tissue culture colour test for assaying the virus and neutralising antibody of foot-and-mouth disease and its application to the measurement of immunity in cattle. Res. vet. Sci. 2, 53.Google Scholar
Moosbrugger, G. A. (1948). Recherches expérimentales sur la fièvre aphteuse. Schweiz. Arch. Tierheilk. 90, 176.Google Scholar
Schneider, B. (1955). Zur Infektiosität der Maul-und-Klauenseuche Adsorbat-Vakzine. Mh. Tierheilk. 7, 81.Google Scholar
Sellers, R. F. (1955). Growth and titration of the viruses of foot-and-mouth disease and vesicular stomatitis in kidney monolayer tissue cultures. Nature, Lond., 176, 547.CrossRefGoogle ScholarPubMed
Skinner, H. H. (1951). Propagation of strains of foot-and-mouth disease virus in unweaned white mice. Proc. R. Soc. Med. 44, 1041.Google ScholarPubMed
Skinner, H. H. (1953). One week old white mice as test animals in foot-and-mouth disease research. Proc. 15th Int. vet. Congr. 1, 195.Google Scholar
Vallée, H., Carré, H. & Rinjard, J. (1926). Sur l'immunisation anti-aphteuse par le virus formolé. Rév. gén. méd. vét. 35, 129.Google Scholar
Waldmann, O. & Köbe, K. (1938). Die aktive Immunisierung des Rindes gegen Maul-und-Klauenseuche. Berl. tierärztl. Wschr. 46, 317.Google Scholar
Wesslen, T. & Dinter, Z. (1957). The inactivation of foot-and-mouth disease virus by formalin. Arch. Virusforschung, 7, 394.Google ScholarPubMed