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Vaccination of man with attentuated live adenovirus

Published online by Cambridge University Press:  15 May 2009

Griselda Hitchock ,
D. A. J. Tyrrell  and
M. L. Bynoe
Griselda Hitchock
Affiliation:
Common Cold Research Unit of the Medical Research Council, Salisbury, Wilts
D. A. J. Tyrrell
Affiliation:
Common Cold Research Unit of the Medical Research Council, Salisbury, Wilts
M. L. Bynoe
Affiliation:
Common Cold Research Unit of the Medical Research Council, Salisbury, Wilts
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Eighteen volunteers were given live adenovirus attenuated by passage in pig kidney tissue culture. Thirteen were given adenovirus Type 7 and five were given adenovirus Type 4. All volunteers who were given Type 7 and who had no homologous neutralizing antibody on inoculation showed antibody rises. Except in one volunteer not in isolation no signficant symptoms were seen.

It is suggested that adenoviruses attenuated in this way might be useful for large-scale vaccination programmes.

Type
Research Article
Information
Journal of Hygiene , Volume 58 , Issue 3 , September 1960 , pp. 277 - 282
Copyright
Copyright © Cambridge University Press 1960

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