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Variations in natural resistance to tuberculosis

Published online by Cambridge University Press:  15 May 2009

David F. Gray ,
Heather Graham-Smith  and
John L. Noble
David F. Gray
Affiliation:
From the School of Bacteriology, University of Melbourne, Parkville N. 2, Victoria, Australia
Heather Graham-Smith
Affiliation:
From the School of Bacteriology, University of Melbourne, Parkville N. 2, Victoria, Australia
John L. Noble
Affiliation:
From the School of Bacteriology, University of Melbourne, Parkville N. 2, Victoria, Australia
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1. ‘Resistant’ and ‘susceptible’ species of animals appear to be more or less equally susceptible to lung infection with equal doses of tubercle bacilli. Therefore it is pertinent to ask whether recognized natural differences in species resistant are in fact significant. For example, in terms of death rates (i.e. of overall resistance) the C57 mouse is at least as susceptible to tuberculosis as the guinea-pig and much more so than man.

2. Resistant, moderately susceptible and susceptible strains of mice as determined by death rates when exposed to large infecting doses, were equally susceptible to intranasal infection with small numbers of tubercle bacilli.

3. A state of tolerance of the parasite by the host lasting for about 3 weeks was observed in all mouse strains, regardless of ultimate strain resistance.

4. Pre-allergic deaths commenced in all groups when the tuberculous processes left insufficient normal lung to support life, but the deaths stopped first in the resistant strain and last in the susceptible strain, coinciding approximately in each strain with the onset of allergy.

5. Acquired immunity, once established, appeared not to vary in quality from one mouse strain to another, at least during 3 months' observation.

6. Racial or strain variations in the resistance of mice to tuberculosis are therefore natural, only in the sense that speed of onset of acquired immunity is probably genetically determined for each strain.

7. It is suggested that both species and racial variations in natural resistance to pulmonary infection are insignificant. Differences in the subsequent course of the disease appear to be explainable by the rapidity, efficiency and duration of the acquired immune response.

Type
Research Article
Information
Journal of Hygiene , Volume 58 , Issue 2 , June 1960 , pp. 215 - 227
Copyright
Copyright © Cambridge University Press 1960

References

REFERENCES

Canetti, G. (1955). The tubercle Bacillus in the Pulmonary Lesions of Man. (revised ed.). New York: Springer.Google Scholar
Dubos, R. J. (1952). A tuberculostatic agent present in animal tissues. Amer. Rev. Tuberc. 63, 119.Google Scholar
Francis, J. (1958). Tuberculosis in Animals and Man. London: Cassell.Google Scholar
Gray, D. F. & Mattinson, M. W. (1952). Detection of small numbers of tubercle bacilli from dispersed cultures. Amer. Rev. Tuberc. 65, 572.Google ScholarPubMed
Gray, D. F. & Jennings, P. A. (1955). Allergy in experimental mouse tuberculosis. Amer. Rev. Tuberc. 72, 171.Google Scholar
Gray, D. F. & Affleck, M. N. (1958). Relationship of allergy to gross lung disease and culturable bacilli in tuberculous mice. Amer. Rev. Tuberc. 78, 226.Google ScholarPubMed
Gray, D. F. (1958). Immunity, natural anergy and artificial desensitization in experimental tuberculosis. Amer. Rev. Tuberc. 78, 235.Google ScholarPubMed
Gray, D. F. (1959). Fate of tubercle bacilli in early experimental infection of the mouse. J. Hyg., Camb., 57, 473.Google ScholarPubMed
Hirsch, J. G. & Dubos, R. J. (1952). The effect of spermine on tubercle bacilli. J. Exp. Med. 95, 191.CrossRefGoogle ScholarPubMed
Hirsch, J. G. (1954). Mechanisms involved in the antimycobacterial activity of certain basic peptides. J. Exp. Med. 99, 79.CrossRefGoogle ScholarPubMed
Kumashiro, A. (1958). Studies on the susceptibility of rats to various strains of Mycobacteria, Parts I, II and III. Acta Tuberc. Japon. 8, 1.Google Scholar
Lurie, M. B. (1944). Experimental epidemiology of tuberculosis. J. Exp. Med. 79, 573.CrossRefGoogle ScholarPubMed
Lurie, M. B. (1950). Native and acquired resistance to tuberculosis. Amer. J. Med. 9, 591.CrossRefGoogle ScholarPubMed
Lurie, M. B., Zapposodi, P. & Tickner, C. (1955). On the nature of genetic resistance to tuberculosis in the light of the host parasite relationships in natively resistant and susceptible rabbits. Amer. Rev. Tuberc. 72, 297.Google Scholar
Mackaness, G. B. (1952). The action of drugs on intracellular tubercle bacilli. J. Path. Bact. 64, 429.CrossRefGoogle ScholarPubMed
Mackaness, G. B. (1954). The growth of tubercle bacilli in monocytes from normal and vaccinated rabbits. Amer. Rev. Tuberc. 69, 495.Google ScholarPubMed
Ratcliffe, H. L. & Palladino, V. S. (1953). Tuberculosis induced by droplet nuclei infection. J. Exp. Med. 97, 61.Google Scholar
Rich, A. R. (1951). The Pathogenesis of Tuberculosis. 2nd edition.Oxford: Blackwell.Google Scholar
Rich, A. R. (1955). Experimental Tuberculosis. Ciba Found. Symp. p. 337. London: S. & A. Churchill Ltd.Google Scholar
Soltys, M. A. (1953). An antituberculous substance in tuberculous organs. J. comp. Path. 63, 147.Google Scholar
Tsuji, S. & Ito, K. (1955). An in vivo method of culturing tubercle bacilli: the chamber method. Amer. Rev. Tuberc. 72, 393.Google Scholar
Wessels, C. C. (1941). Tuberculosis in the rat. Parts I, II and III. Amer. Rev. Tuberc. 43, 449, 459, 637.Google Scholar