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Virological and epidemiological studies on an outbreak of aseptic meningitis caused by echovirus 4 in northern Japan in 1964*

Published online by Cambridge University Press:  15 May 2009

Yorio Hinuma ,
Katsumi Uruno ,
Morihiro Morita ,
Nakao Ishida  and
Tooru Nakao
Yorio Hinuma
Affiliation:
Department of Bacteriology, Tohoku University School of Medicine, Sendai, Japan
Katsumi Uruno
Affiliation:
Department of Bacteriology, Tohoku University School of Medicine, Sendai, Japan
Morihiro Morita
Affiliation:
Department of Bacteriology, Tohoku University School of Medicine, Sendai, Japan
Nakao Ishida
Affiliation:
Department of Bacteriology, Tohoku University School of Medicine, Sendai, Japan
Tooru Nakao
Affiliation:
Pediatric Clinic, Aomori Prefectural Central Hospital, Aomori, Japan
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During the summer and autumn of 1964, echovirus 4 was found widely distributed in northern Japan; this virus was associated with localized outbreaks of iaseptic meningitis in many regions. The evidence that the echovirus was aetio-logically related to aseptic meningitis was shown by the virus isolation from cerebrospinal fluids and faeces and the serodiagnosis of paired sera in many patients: Age-specific sero-immunity and morbidity rate suggested that echovirus 4 had spread extensively in about 1954. The strains of echovirus 4 isolated in the 1964; epidemic were similar to the prototype strain, Pesascek, in biological characteristics.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 1 , March 1966 , pp. 53 - 64
Copyright
Copyright © Cambridge University Press 1966

References

REFERENCES

Barron, A. L. & Karzon, D. T. (1961). Characteristics of ECHO 4 (Shropshire) virus isolated during epidemic of aseptic meningitis. J. Immun. 87, 608–15.CrossRefGoogle ScholarPubMed
Bell, E. J. (1964). An outbreak of meningitis due to ECHO virus type 4 in Scotland, 1963. Lancet, i, 1195–6.CrossRefGoogle Scholar
Forbes, J. A. (1958). Meningitis in Melbourne due to ECHO virus. Med. J. Aust. i, 246–8CrossRefGoogle Scholar
Hayakawa, Y. (1964). Epidemiological and serological studies on aseptic meningitis and encephalitis of viral etiology. Shonika Kiyo, 10, 109–31. (In Japanese with English abstract.)Google Scholar
Hlnuma, Y., Murai, Y., Fukuda, M., Numazaki, Y., Ishida, N. & Nakao, T. (1964). An outbreak of aseptic meningitis associated with Coxsackie B 5 and A 9 viruses in Northern Japan, 1961. Virological and serological studies. J. Hyg., Camb., 62, 159–70.Google Scholar
Hinuma, Y., Murai, Y. & Nakao, T. (1965). Two outbreaks of echovirus 14 infection: a possible interference with oral poliovirus vaccine and a probable association with aseptic meningitis. J. Hyg., Camb., 63, 277–84.CrossRefGoogle Scholar
Johnsson, T., Böttiger, M. & Löfdahl, A. (1958). An outbreak of aseptic meningitis with rubella-like rash probably caused by ECHO virus type 4. Arch. ges. Virusforsch. 8, 306–17.CrossRefGoogle ScholarPubMed
Karzon, D. T., Eckert, G. L., Barron, A. L., Hyner, N. S. & Winkelstein, W. Jr. (1961). Aseptic meningitis epidemic due to ECHO 4 virus. Am. J. Dis. Child. 101, 610–22.Google ScholarPubMed
Kono, R., Ashihara, Y., Hamada, C.Kawakami, K., Akagi, N., Furukawa, M. & Miyao, M. (1960). Studies on the epidemiology of Coxsackie B5 virus meningitis. Rep. Inst. Virus Res. Kyoto, 3, 99–113.Google Scholar
Krech, U. (1957). Über das Vorkommen von Echo-Virus in der Schweitz. Sohweiz. med. Wschr. 87, 558–60.Google Scholar
Levan, P. H., Chick, E. W., Koto, I. L., Chin, T. D. Y., Herren, R. H. & Furcolow, M. L. (1957). An epidemic illness associated with a recently recognized enteric virus (ECHO virus type 4). I. Epidemiologic and clinical features. Am. J. Hyg. 66, 63–75.Google Scholar
Malherbe, H., Harwin, R. & Smith, A. H. (1957). An outbreak of aseptic meningitis associated with ECHO virus type 4. S. Afr. med. J. 31, 1261–4.Google ScholarPubMed
Munk, K. & Nasemann, T. (1959). Untersuchungen über die Ätiolgie der in Süddeutschland beobachteten Fälle des variablen infektiösen Exanthems; Isolierung eines ECHO-virus. Klin. Wschr. 37, 371–4.CrossRefGoogle Scholar
Nakao, T., Nitta, T., Miura, R., Ogata, K., Kume, T., Nobuta, K. & Hinuma, Y. (1964). Clinical and epidemiological studies on an outbreak of aseptic meningitis caused by Coxsackie B5 and A9 viruses in Aomori in 1961. Tohoku. J. exp. Med. 83, 94–102.Google Scholar