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WRL 105 strain live attenuated influenza vaccine; comparison of one and two dose schedules

Published online by Cambridge University Press:  15 May 2009

A. E. J. Evans ,
E. Letley ,
R. P. Ferris  and
D. S. Freestone
A. E. J. Evans
Affiliation:
Works Medical Officer, I.C.I. Organics Division, Manchester
E. Letley
Affiliation:
The Welicome Research Laboratories, Beckenham, Kent
R. P. Ferris
Affiliation:
The Welicome Research Laboratories, Beckenham, Kent
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Summary

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Haemagglutinating inhibiting antibody (HAI) responses were determined and clinical reactions recorded in 162 adult volunteers who received either 1 or 2 intranasal doses of 107·0 EID 50 WRL 105 strain live influenza vaccine or placebo. After administration of a single dose of vaccine significant antibody responses were obtained in 69 (70%) of 98 volunteers with initial antibody titres of ≤ 1/20. Of the 70 volunteers who received a second dose of vaccine, 62 provided a further post-vaccination sample of serum, and only 3 (4·8 %), who had not responded to the first dose of vaccine, produced a significant antibody response.

Local, upper respiratory and constitutional symptoms were recorded more frequently after the administration of a first dose of vaccine than after placebo or a second dose of vaccine. The symptoms were of a minor nature except in one volunteer who, after the first dose of vaccine, developed influenzal symptoms followed by bronchitis.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 3 , December 1976 , pp. 327 - 332
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

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