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Genetic influence on East African running success

Published online by Cambridge University Press:  09 March 2007

Robert A Scott ,
Colin Moran ,
Richard H Wilson ,
Will H Goodwin  and
Yannis P Pitsiladis
Robert A Scott
Affiliation:
International Centre for East African Running Science (ICEARS), Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
Colin Moran
Affiliation:
International Centre for East African Running Science (ICEARS), Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
Richard H Wilson
Affiliation:
International Centre for East African Running Science (ICEARS), Institute of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
Will H Goodwin
Affiliation:
Department of Forensic and Investigative Science, University of Central Lancashire, Preston PR1 2HE, UK
Yannis P Pitsiladis*
Affiliation:
Department of Forensic and Investigative Science, University of Central Lancashire, Preston PR1 2HE, UK
*
* Email:Y.Pitsiladis@bio.gla.ac.uk
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Abstract

East African athletes now dominate international distance running events from the 800 m to the marathon. Explanations for their phenomenal success have included optimal environmental conditions for developing distance running performance, psychological advantage and advantageous physiological characteristics. It is well established that genetics plays a role in determining inter-individual differences in exercise performance and adaptation to training stimuli. It is not known, however, to what extent inter-population differences (i.e. between ‘races’ and/or ethnic groups) in exercise performance can be attributed to genetics. There have been considerations that ‘black’ athletes are genetically adapted towards performance, given the concurrent success of athletes of West African ancestry in sprint events. However, the current notion of ‘race’ is not universally accepted, and genetic differences within and between populations are not clearly delineated by geographical or ethnic categorizations. Recent findings from mitochondrial DNA show that the populations from which Ethiopian athletes are drawn have not been isolated populations and are not genetically distinct from other Ethiopians. Y-chromosome analysis of the same population shows concurrent results, although some differences are present between athletes and the general Ethiopian population, suggesting an influence of the Y chromosome on athlete status in Ethiopia. It is concluded that there may be a role for genetics in the success of East African athletes; however, any genetic component to their success is unlikely to be limited to East Africans and is more likely to be found in other populations. At present it is unjustified to implicate a role for genetics in the success of East African runners when no genes have been identified as being important to their performance.

Keywords

KenyaEthiopiaathleticsgeneticsmitochondrial DNAY chromosome
Type
Review Article
Information
Equine and Comparative Exercise Physiology , Volume 1 , Issue 4 , November 2004 , pp. 273 - 280
Copyright
Copyright © Cambridge University Press 2004

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References

1Phillips, JC (1976). Toward an explanation of racial variation in top-level sports participation. International Review of Sports and Sociology 113: 39–55.CrossRefGoogle Scholar
2Entine, J (2001). In: Entine, J, Salles, G and Kearney, JT (eds.) Why Black Athletes Dominate Sports and Why We are Afraid to Talk about it. New YorkPublic Affairs.Google Scholar
3Pitsiladis, YP, Onywera, VO, Geogiades, E, O'Connell, W and Boit, MK (2004). The dominance of Kenyans in distance running. Equine and Comparative Exercise Physiology 14: 285–291.CrossRefGoogle Scholar
4Larsen, HB (2003). Kenyan dominance in distance running. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 136(1): 161–170.CrossRefGoogle ScholarPubMed
5Entine, J (2001). Race and sport. The race to the swift – if the swift have the right ancestry. Peak Performance Special Issue. Race and Genetics 158: 1–6.Google Scholar
6Saltin, B, Kim, CK, Terrados, N, Larsen, H, Svedenhag, J and Rolf, CJ (1995). Morphology, enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners. Scandinavian Journal of Medicine & Science in Sports 5(1) 222–230.CrossRefGoogle ScholarPubMed
7Saltin, B (1996). Exercise and the environment: focus on altitude. Research Quarterly for Exercise and Sport 67: Suppl. 3 S1–S10CrossRefGoogle ScholarPubMed
8Bale, J and Sang, J (1996). Kenyan Running: Movement Culture, Geography, and Global Change. London: Frank Cass.Google Scholar
9Scott, RA, Georgiades, E, Wilson, RH, Goodwin, WH, Wolde, B and Pitsiladis, YP (2003). Demographic characteristics of elite Ethiopian endurance runners. Medicine and Science in Sports and Exercise 35(10): 1727–1732.CrossRefGoogle ScholarPubMed
10Fagard, R, Bielen, E and Amery, A (1991). Heritability of aerobic power and anaerobic energy generation during exercise. Journal of Applied Physiology 70(1): 357–362.CrossRefGoogle ScholarPubMed
11Lesage, R, Simoneau, JA, Jobin, J, Leblanc, J and Bouchard, C (1985). Familial resemblance in maximal heart rate, blood lactate and aerobic power. Human Heredity 35(3): 182–189.CrossRefGoogle ScholarPubMed
12Klissouras, V (1997). Heritability of adaptive variation: an old problem revisited. Journal of Sports Medicine and Physical Fitness 37(1): 1–6.Google ScholarPubMed
13Perusse, L, Rankinen, T, Rauramaa, R, Rivera, MA, Wolfarth, B and Bouchard, C (2003). The human gene map for performance and health-related fitness phenotypes: the 2002 update. Medicine and Science in Sports and Exercise 35(8): 1248–1264.CrossRefGoogle ScholarPubMed
14Rankinen, T, Perusse, L, Rauramaa, R, Rivera, MA, Wolfarth, B and Bouchard, C (2001). The human gene map for performance and health-related fitness phenotypes. Medicine and Science in Sports and Exercise 33(6): 855–867.CrossRefGoogle ScholarPubMed
15Rankinen, T, Perusse, L, Rauramaa, R, Rivera, MA, Wolfarth, B and Bouchard, C (2002). The human gene map for performance and health-related fitness phenotypes: the 2001 update. Medicine and Science in Sports and Exercise 34(8): 1219–1233.CrossRefGoogle ScholarPubMed
16Taylor, RR, Mamotte, CD, Fallon, K, van Bockxmeer, FM (1999). Elite athletes and the gene for angiotensin-converting enzyme. Journal of Applied Physiology 87(3): 1035–1037.CrossRefGoogle ScholarPubMed
17Gayagay, G, Yu, B, BHambly, B, Boston, T, Hahn, A and Celermajer, DS (1998). Elite endurance athletes and the ACE I allele – the role of genes in athletic performance. Human Genetics 103(1): 48–50.CrossRefGoogle ScholarPubMed
18Woods, D, Hickman, M, Jamshidi, Y, Brull, D, Vassiliou, V and Jones, A (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Human Genetics 108(3): 230–232.CrossRefGoogle Scholar
19Nazarov, IB, Woods, DR, Montgomery, HE, Shneider, OV, Kazakov, VI and Tomilin, NV (2001). The angiotensin converting enzyme I/D polymorphism in Russian athletes. European Journal of Human Genetics 9(10): 797–801.CrossRefGoogle ScholarPubMed
20Rankinen, T, Wolfarth, B, Simoneau, JA, Maier-Lenz, D, Rauramaa, R and Rivera, MA (2000). No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. Journal of Applied Physiology 88(5): 1571–1575.CrossRefGoogle ScholarPubMed
21Rigat, B, Hubert, C, Alhenc-Gelas, F, Cambien, F, Corvol, P and Soubrier, F (1990). An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. Journal of Clinical Investigation 86(4): 1343–1346.CrossRefGoogle ScholarPubMed
22Woods, DR, Brull, D and Montgomery, HE (2000). Endurance and the ACE I/D polymorphism. Science Progress 83: 317–336.Google ScholarPubMed
23Myerson, S, Hemingway, H, Budget, R, Martin, J, Humphries, S and Montgomery, H (1999). Human angiotensin I-converting enzyme gene and endurance performance. Journal of Applied Physiology 87(4): 1313–1316.CrossRefGoogle ScholarPubMed
24Payne, J and Montgomery, H (2004). Angiotensin-converting enzyme and human physical performance. Equine and Comparative Exercise Physiology 1(4): 255–260.CrossRefGoogle Scholar
25MacArthur, DG and North, KN (2004). A gene for speed? The evolution and function of alpha-actinin-3. Bioessays 26(7): 786–795.CrossRefGoogle ScholarPubMed
26Yang, N, MacArthur, DG, Gulbin, JP, Hahn, AG, Beggs, AH and Easteal, S (2003). ACTN3 genotype is associated with human elite athletic performance. American Journal of Human Genetics 73(3): 627–631.CrossRefGoogle ScholarPubMed
27Rivera, MA, Dionne, FT, Wolfarth, B, Chagnon, M, Simoneau, JA and Perusse, L (1997). Muscle-specific creatine kinase gene polymorphisms in elite endurance athletes and sedentary controls. Medicine and Science in Sports and Exercise 29(11): 1444–1447.CrossRefGoogle ScholarPubMed
28Rivera, MA, Dionne, FT, Simoneau, JA, Perusse, L, Chagnon, M and Chagnon, Y (1997). Muscle-specific creatine kinase gene polymorphism and VO 2max in the HERITAGE Family Study. Medicine and Science in Sports and Exercise 29(10): 1311–1317.CrossRefGoogle Scholar
29Yu, N, Chen, FC, Ota, S, Jorde, LB, Pamilo, P and Patthy, L (2002). Larger genetic differences within Africans than between Africans and Eurasians. Genetics 161(1): 269–274.CrossRefGoogle ScholarPubMed
30Bouchard, C (1988). Genetic basis of racial differences. Canadian Journal of Sport Sciences 13(2): 104–108.Google ScholarPubMed
31Burchard, EG, Ziv, E, Coyle, N, Gomez, SL, Tang, H and Karter, AJ (2003). The importance of race and ethnic background in biomedical research and clinical practice. New England Journal of Medicine 348(12): 1170–1175.CrossRefGoogle ScholarPubMed
32Ingman, M, Kaessmann, H, Paabo, S and Gyllensten, U (2000). Mitochondrial genome variation and the origin of modern humans. Nature 408(6813): 708–713.CrossRefGoogle ScholarPubMed
33Cooper, RS, Kaufman, JS and Ward, R (2003). Race and genomics. New England Journal of Medicine 348(12): 1166–1170.CrossRefGoogle ScholarPubMed
34Wilson, JF, Weale, ME, Smith, AC, Gratrix, F, Fletcher, B and Thomas, MG (2001). Population genetic structure of variable drug response. Nature Genetics 29(3): 265–269.CrossRefGoogle ScholarPubMed
35Pearce, N, Foliaki, S, Sporle, A and Cunningham, C (2004). Genetics, race, ethnicity, and health. British Medical Journal 328(7447): 1070–1072.CrossRefGoogle ScholarPubMed
36Scott, RA, Wilson, RH, Goodwin, WH, Moran, CN, Georgiades, E and Wolde, B (2004). Mitochondrial DNA lineages of elite Ethiopian athletes. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology (submitted for publication).Google Scholar
37Dionne, FT, Turcotte, L, Thibault, MC, Boulay, MR, Skinner, JS and Bouchard, C (1993). Mitochondrial DNA sequence polymorphism, VO 2max, and response to endurance training. Medicine and Science in Sports and Exercise 25(7): 766–774.CrossRefGoogle Scholar
38Murakami, H, Ota, A, Simojo, H, Okada, M, Ajisaka, R and Kuno, S (2002). Polymorphisms in control region of mtDNA relates to individual differences in endurance capacity or trainability. Japanese Journal of Physiology 52(3): 247–256.Google ScholarPubMed
39Rupert, JL (2003). The search for genotypes that underlie human performance phenotypes. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 136(1): 191–203.CrossRefGoogle ScholarPubMed
40Ruiz-Pesini, E, Mishmar, D, Brandon, M, Procaccio, V and Wallace, DC (2004). Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 303(5655): 223–236.CrossRefGoogle ScholarPubMed
41Anderson, S, Bankier, AT, Barrell, BG de, Bruijn, MH, Coulson, AR and Drouin, J (1981). Sequence and organization of the human mitochondrial genome. Nature 290(5806): 457–465.CrossRefGoogle ScholarPubMed
42Maca-Meyer, N, Gonzalez, AM, Larruga, JM, Flores, C and Cabrera, VM (2001). Major genomic mitochondrial lineages delineate early human expansions. BMC Genetics 2(1): 13CrossRefGoogle ScholarPubMed
43Macaulay, V, Richards, M, Hickey, E, Vega, E, Cruciani, F and Guida, V (1999). The emerging tree of West Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. American Journal of Human Genetics 64(1): 232–249.CrossRefGoogle ScholarPubMed
44Richards, M, Macaulay, V, Hickey, E, Vega, E, Sykes, B and Guida, V (2000). Tracing European founder lineages in the Near Eastern mtDNA pool. American Journal of Human Genetics 67(5): 1251–1276.CrossRefGoogle ScholarPubMed
45Salas, A, Richards, M, De la Fe, T, Lareu, MV, Sobrino, B and Sanchez-Diz, P (2002). The making of the African mtDNA landscape. American Journal of Human Genetics 71(5): 1082–1111.CrossRefGoogle ScholarPubMed
46Passarino, G, Semino, O, Quintana-Murci, L, Excoffier, L, Hammer, M and Santachiara-Benerecetti, AS(1998). Different genetic components in the Ethiopian population, identified by mtDNA and Y-chromosome polymorphisms. American Journal of Human Genetics 62(2): 420–434.CrossRefGoogle ScholarPubMed
47Semino, O, Santachiara-Benerecetti, AS, Falaschi, F, Cavalli-Sforza, LL and Underhill, PA (2002). Ethiopians and Khoisan share the deepest clades of the human Y-chromosome phylogeny. American Journal of Human Genetics 70(1): 265–268.CrossRefGoogle ScholarPubMed
48Rando, JC, Pinto, F, Gonzalez, AM, Hernandez, M, Larruga, JM and Cabrera, VM (1998). Mitochondrial DNA analysis of northwest African populations reveals genetic exchanges with European, near-eastern, and sub-Saharan populations. Annals of Human Genetics 62: 531–550.CrossRefGoogle ScholarPubMed
49Ellis, N, Hammer, M, Hurles, ME, Jobling, MA, Karafet, T and King, TE (2002). A nomenclature system for the tree of human Y-chromosomal binary haplogroups. Genome Research 12: 339–348.Google Scholar
50Jobling, MA and Tyler-Smith, C (2003). The human Y chromosome: an evolutionary marker comes of age. Nature Reviews. Genetics 4(8): 598–612.CrossRefGoogle ScholarPubMed
51Underhill, PA, Shen, P, Lin, AA, Jin, L, Passarino, G and Yang, WH (2000). Y chromosome sequence variation and the history of human populations. Nature Genetics 26(3): 358–361.CrossRefGoogle ScholarPubMed
52Moran, CN, Scott, RA, Adams, SM, Warrington, SJ, Jobling, MA and Bosch, E (2004). Y chromosome haplogroups of elite Ethiopian endurance runners Human Genetics (submitted for publication)Google Scholar
53Skaletsky, H, Kuroda-Kawaguchi, T, Minx, PJ, Cordum, HS, Hillier, L and Brown, LG (2003). The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423(6942): 825–837.CrossRefGoogle ScholarPubMed
54Beall, CM (2003). High-altitude adaptations. Lancet 362: S14–S15CrossRefGoogle ScholarPubMed
55Moore, LG, Shriver, M, Bemis, L, Hickler, B, Wilson, M and Brutsaert, T (2004). Maternal adaptation to high-altitude pregnancy: an experiment of nature – a review. Placenta 25: Suppl. A S60–S71CrossRefGoogle ScholarPubMed
56Montgomery, HE, Marshall, R, Hemingway, H, Myerson, S, Clarkson, P and Dollery, C (1998). Human gene for physical performance. Nature 393(6682): 221–222.CrossRefGoogle ScholarPubMed
57Baker, J and Horton, S (2003). East African running dominance revisited: a role for stereotype threat?. British Journal of Sports Medicine 37(6): 553–555.CrossRefGoogle ScholarPubMed