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Comparison of oral dolasetron and ondansetron in the prophylaxis of postoperative nausea and vomiting in children
Published online by Cambridge University Press: 11 July 2005
Extract
Summary
Background and objective: In a randomized, placebo-controlled, double-blind trial, we compared the efficacy of oral dolasetron and ondansetron in preventing postoperative nausea and vomiting in children after various surgical operations.
Methods: Children were assigned randomly to one of three groups (each contained 50 children) to receive dolasetron 1.8 mg kg−1 or ondansetron 0.15 mg kg−1 orally, or a placebo. All children received methylene blue capsules (10 mg) orally as an indicator before the induction of anaesthesia. Postoperatively, contamination of the mouth and the endotracheal tube by methylene blue was recorded, and postoperative nausea and vomiting was recorded for 0–1, 1–24 and 0–24 h. Metoclopramide (0.1 mg kg−1) intravenously was used as the rescue antiemetic.
Results: In the 0–1 h period after operation, there were no differences between the groups. In the 1–24 h period, dolasetron was significantly better than placebo (nausea 8 versus 24%; vomiting 4 versus 20%; total nausea and vomiting scores 16 versus 48%). Over the 0–24 h period, both dolasetron and ondansetron were significantly better than placebo (nausea 16 versus 26 versus 40%), vomiting (8 versus 16 versus 30%), and total nausea and vomiting scores (32 versus 48 versus 78%). There were no significant differences between dolasetron and ondansetron. There was no important methylene blue contamination, and little use of rescue metoclopramide. There were no important adverse events.
Conclusions: Prophylactic oral dolasetron and ondansetron were effective in reducing postoperative nausea and vomiting in children.
Keywords
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- © 2003 European Society of Anaesthesiology
References
Lerman J. Surgical and patient factors involved in postoperative nausea and vomiting. Br J Anaesth 1992; 69 (Suppl 1): 245.Google Scholar
Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992; 77: 16–84.Google Scholar
Camu F, Lauwers MH, Verbessem D. Incidence and aetiology of postoperative nausea and vomiting. Eur J Anaesthesiol 1992; 9 (Suppl 6): 25–31.Google Scholar
Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs 2000; 59: 213–243.Google Scholar
Dimmitt DC, Choo YS, Martin LA, Arumugham T, Hahne WF, Weir SJ. Intravenous pharmacokinetics and absolute oral bioavailability of dolasetron in healthy volunteers: part 1. Biopharm Drug Dispos 1999; 20: 29–39.Google Scholar
Balfour JA, Goa KL. Dolasetron. A review of its pharmacology and therapeutic potential in the management of nausea and vomiting induced by chemotherapy, radiotherapy or surgery. Drugs 1997; 54: 273–298.Google Scholar
Domino KB, Anderson EA, Polissar NL, Posner KL. Comparison efficacy and safety of ondansetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting: a meta-analysis. Anesth Analg 1999; 88: 1370–1379.Google Scholar
Piper SN, Triem JG, Maleck WH, Fent MT, Hüttner I, Boldt J. Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy. Eur J Anaesthesiol 2001; 18: 251–256.Google Scholar
Sadhasivam S, Shende D, Madan R. Prophylactic ondansetron in prevention of postoperative nausea and vomiting following pediatric strabismus surgery: a dose– response study. Anesthesiology 2000; 92: 1035–1042.Google Scholar
Warriner CB, Knox D, Belo S, Cole C, Finegan BA, Perreault L. Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. The Canadian Dolasetron Study Group. Can J Anesth 1997; 44: 1167–1173.Google Scholar
Kenny GNC, Oates JDL, Leeser J, Rawbotham DJ. Efficacy of orally administered ondansetron in prevention of postoperative nausea and vomiting. Br J Anaesth 1992; 68: 466.Google Scholar
Triem JG, Piper SN, Maleck WH, Schenck A, Schmidt CC, Boldt J. Prevention of postoperative nausea and vomiting after hysterectomy with oral dolasetron, intravenous dehydrobenzperidol or a combination of both substances. Anasthesiol Intensivmed Notfallmed Schmerzther 1999; 34: 340–344.Google Scholar
Dillier CM, Weiss M, Gerber AC. Tropisetron for prevention of nausea and vomiting in children undergoing tonsillectomy and/or adenoidectomy. Anaesthesist 2000; 49: 275–278.Google Scholar
Fujii Y, Toyooka H, Tanaka H. A granisetron–droperidol combination prevents postoperative vomiting in children. Anesth Analg 1998; 87: 761–765.Google Scholar
Pappas ALS, Sukhani R, Hotaling AJ, et al. The effect of preoperative dexamethasone on the immediate and delayed postoperative morbidity in children undergoing adenotonsillectomy. Anesth Analg 1998; 87: 57–61.Google Scholar
Gibbs CP, Modell JH. Pulmonary aspiration of gastric contents: pathophysiology, prevention and management. In: Miller RD, ed. Anesthesia, 4th edn. New York, USA: Churchill-Livingstone, 1994: 1437–1464.
Illing L, Duncan PG, Yip R. Gastroesophageal reflux during anaesthesia. Can J Anaesth 1992; 39: 466–470.Google Scholar
Kluger MT, Short TG. Aspiration during anaesthesia: a review of 133 cases from the Australian Anaesthetic Incident Monitoring Study (AIMS). Anaesthesia 1999; 54: 19–26.Google Scholar
Cote CJ, Goudsouzian NG, Liu LM, Dedrick DF, Szyfelbein SK. Assessment of risk factors related to the acid aspiration syndrome in pediatric patients-gastric pH and residual volume. Anesthesiology 1982; 56: 70–72.Google Scholar