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Is an alkalinized lignocaine solution a better topical anaesthetic for intratracheal application?

Published online by Cambridge University Press:  16 August 2006

C. Konrad ,
H. Gerber ,
T. Schnider  and
G. Schüpfer
C. Konrad
Affiliation:
Institute of Anaesthesiology and Intensive Care, Kantonsspital, CH - 6000 16 Lucerne, Switzerland
H. Gerber
Affiliation:
Institute of Anaesthesiology and Intensive Care, Kantonsspital, CH - 6000 16 Lucerne, Switzerland
T. Schnider
Affiliation:
Institute of Anaesthesiology and Intensive Care, Kantonsspital, CH - 6000 16 Lucerne, Switzerland
G. Schüpfer
Affiliation:
Institute of Anaesthesiology and Intensive Care, Kantonsspital, CH - 6000 16 Lucerne, Switzerland
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Abstract

Topical anaesthesia of the trachea is used to avoid coughing during emergence from anaesthesia. This study was designed to compare the effects of an alkalinized lignocaine and plain lignocaine solution given intratracheally. After institutional approval and written informed consent, 30 patients were randomized into three groups and received in a double-blind fashion: lignocaine, alkalinized lignocaine and normal saline for control. After application of normal or alkalinized lignocaine the tolerance to the tube was significantly better during extubation (P = 0.001). Noradrenaline levels were significantly diminished in the lignocaine groups (P < 0.05). Plain and alkalinized lignocaine solutions for topical anaesthesia significantly improved tolerance to the tracheal tube during emergence from anaesthesia. Plain and alkalinized lignocaine given directly before intubation reduced the sympathomimetic stress response resulting in a lower noradrenaline concentration and a reduced heart rate.

Keywords

lignocaineintratracheal topical anaesthesiaintubation
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 6 , November 1997 , pp. 616 - 622
Copyright
1997 European Society of Anaesthesiology

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