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Preconditioning and protection against ischaemia–reperfusion in non-cardiac organs: a place for volatile anaesthetics?

Published online by Cambridge University Press:  01 September 2007

G. Minguet ,
J. Joris  and
M. Lamy
G. Minguet*
Affiliation:
University of Liège, Department of Anaesthesia and Intensive Care Medicine, Belgium
J. Joris
Affiliation:
University of Liège, Department of Anaesthesia and Intensive Care Medicine, Belgium
M. Lamy
Affiliation:
University of Liège, Department of Anaesthesia and Intensive Care Medicine, Belgium
*
Correspondence to: Grégory Minguet, Department of Anaesthesia and Intensive Care Medicine, CHU de Liège, B35 Domaine Universitaire du Sart Tilman, B-4000 Liège 1, Belgium. E-mail: gminguet@chu.ulg.ac.be; Tel: +32 4 366 71 79; Fax: +32 4 366 76 36
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Summary

There is an increasing body of evidence that volatile anaesthetics protect myocardium against ischaemic insult by a mechanism termed ‘anaesthetic preconditioning’. Anaesthetic preconditioning and ischaemic preconditioning share several common mechanisms of action. Since ischaemic preconditioning has been demonstrated in organs other than the heart, anaesthetic preconditioning might also apply in these organs and have significant clinical applications in surgical procedures carrying a high risk of ischaemia–reperfusion injury. After a brief review on myocardial preconditioning, experimental and clinical data on preconditioning in non-cardiac tissues will be presented. Potential benefits of anaesthetic preconditioning during non-cardiac surgery will be addressed.

Keywords

ANAESTHESIA: ANAESTHETICS INHALATIONISCHAEMIA–REPERFUSIONMITOCHONDRIAISCHAEMIC PRECONDITIONING
Type
Review
Information
European Journal of Anaesthesiology , Volume 24 , Issue 9 , September 2007 , pp. 733 - 745
Copyright
Copyright © European Society of Anaesthesiology 2007

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