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Propofol inhibits potassium chloride induced contractions of isolated human umbilical vessels

Published online by Cambridge University Press:  27 January 2006

E. Caliskan ,
Z. Kayhan  and
H. Tufan
E. Caliskan
Affiliation:
Baskent University, Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Anaesthesiology, Adana, Turkey
Z. Kayhan
Affiliation:
Baskent University, Faculty of Medicine, Department of Anaesthesiology, Ankara, Turkey
H. Tufan
Affiliation:
Baskent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
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Abstract

Summary

Background and objective: We have evaluated the effects of propofol and its relationship with K+ channels on human isolated umbilical vessels. Methods: Umbilical vessel rings were suspended in isolated organ baths containing Krebs–Ringer solution. In the first series of experiments the effect of propofol (10−9–10−4M) was examined in a concentration-dependent manner on umbilical vessels precontracted with KCl (60 mmol). In the second series, these effects were studied in the presence of tetraethylammonium. Results: A mild contraction was produced by low dose propofol in both precontracted umbilical artery and umbilical vein segments. 10−4M propofol caused significant relaxation in both umbilical artery and umbilical vein. The relaxation response was significantly reduced by the addition of 10−1 M tetraethylammonium. Conclusion: These results suggested that the responses of propofol on KCl-induced contractions of both umbilical artery and vein were dose dependent, and this effect involved Ca2+ activated K+ channels.

Keywords

INTRAVENOUS ANAESTHETIC AGENTS, propofolUMBILICAL ARTERIESUMBILICAL VEINSPOTASSIUM CHANNELSVASOCONSTRICTION
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 5 , May 2006 , pp. 411 - 417
Copyright
2006 European Society of Anaesthesiology

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References

Dailland P, Cockshott I, Lirzin DJet al. Intravenous propofol during Caesarean section: placental transfer, concentrations in breast milk and neonatal effects. A preliminary study. Anesthesiology 1989; 71: 827–834.Google Scholar
Imura N, Shiraishi Y, Katsuya H, Itoh T. Effect of propofol on norepinephrine-induced increases in [Ca++]i and force in smooth muscle of the rabbit mesenteric resistance artery. Anesthesiology 1998; 88: 1566–1578.Google Scholar
Morgan EG, Mikhail SM. Maternal and fetal physiology and anesthesia. In: Appleton and Lange: Clinical Anesthesiology, 3rd edn.New York, USA: McGraw-Hill Companies, 2002: 804–818.
Gin T. Pharmacokinetic optimisation of general anaesthesia in pregnancy. Clin Pharmacokin Ther 1993; 25: 59–70.Google Scholar
Fields AS, Eric M. Obstetric analgesia and anaesthesia. A Review. Primary Care 1993; 20: 705–712.Google Scholar
Nakamura K, Hatano Y, Hirakata H, Nishiwada M. Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. Br J Anaesth 1992; 68: 193–197.Google Scholar
Robinson BJ, Ebert JT, Colinco MD. Mechanisms whereby propofol mediates peripheral vasodilatation in humans. Anesthesiology 1997; 86: 64–72.Google Scholar
Park KW, Lynch C, Roger AJ. Effects of propofol and thiopental in isolated rat aorta and pulmonary artery. Anesthesiology 1992; 77: 956–963.Google Scholar
Yamanoue T, Brum MJ, Estafanous FG. Vasodilatation and mechanism of action of propofol in porcine coronary artery. Anesthesiology 1994; 81: 443–451.Google Scholar
Wallerstedt MS, Törnebrandt K, Bodelson M. Relaxant effects of propofol on human omental arteries and veins. Br J Anaesth 1998; 80: 655–659.Google Scholar
Bently GN, Gent JP, Goodchild CS. Vascular effects of propofol: smooth muscle relaxation in isolated veins and arteries. J Pharmacia Pharmacol 1995; 23: 34–42.Google Scholar
Introna RPS, Pruett JK, Yodlowski EH. Direct effects of propofol on canine coronary artery ring tension. Gen Pharmacol 1993; 24: 497–502.Google Scholar
Moreno L, MartinezCuesta MA, Muedra V, Beltran B, Esplugues J. Role of the endothelium in the relaxation induced by propofol and thiopental in isolated arteries from man. J Pharm Pharmacol 1997; 49: 430–432.Google Scholar
Tanabe K, Kozawa O, Kaida Tet al. Inhibitory effects of propofol on intracellular signaling by endothelin-1 in aortic smooth muscle cells. Anesthesiology 1998; 88: 452–460.Google Scholar
He Y-L, Seno H, Tsujimoto S, Tashiro C. The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion. Anesth Analg 2001; 93: 151–156.Google Scholar
Valtonen M, Kanto J, Rosenberg P. Comparison of propofol and thiopentone for induction of anaesthesia for elective Caesarean section. Anaesthesia 1989; 44: 758–762.Google Scholar
Errasti EA, Werneck de Avellar CM, Daray MF. Human umbilical vein vasoconstriction induced by epinephrine acting on α1B-adrenoceptor subtype. Am J Obstet Gynecol 2003; 189: 1472–1480.Google Scholar
Gacar N, Gok S, Kalyoncu N. The effect of endothelium on the response to propofol on bovine coronary artery. Acta Anaesth Scand 1995; 39: 1080–1083.Google Scholar
Wallerstedt MS, Törnebrandt K, Bodelson M. Relaxant effects of propofol on human omental arteries and veins. Br J Anaesth 1998; 80: 655–659.Google Scholar
Goodchild CS, Serrao JLM. Cardiovascular effects of propofol in the anaesthetized dog. Br J Anaesth 1989; 63: 87–92.Google Scholar
Kirkpatrick T, Cockshott D, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth 1988; 60: 146–150.Google Scholar
Alcaraz SA, Quintana MB, Laguarda M. Placental transfer and neonatal effects of propofol in Caesarean section. J Clin Pharm Ther 1998; 23: 19–23.Google Scholar
He Y-L, Tsujimoto S, Tanimoto M, Okutani R, Murakawa K, Tashiro C. Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro. Br J Anaesth 2000; 85: 281–286.Google Scholar