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Cardiovascular effects of Org 9487 under isoflurane anaesthesia in man

Published online by Cambridge University Press:  16 August 2006

C. Osmer ,
K. Wulf ,
C. Vögele ,
B. Zickmann  and
G. Hempelmann
C. Osmer
Affiliation:
Department of Anaesthesiology, Justus-Liebig-University, Rudolf-Buchheim Str., D-35392 Giessen, Germany
K. Wulf
Affiliation:
Department of Anaesthesiology, Justus-Liebig-University, Rudolf-Buchheim Str., D-35392 Giessen, Germany
C. Vögele
Affiliation:
Department of Psychology, Philipps University, Marburg, Germany
B. Zickmann
Affiliation:
Department of Anaesthesiology, Justus-Liebig-University, Rudolf-Buchheim Str., D-35392 Giessen, Germany
G. Hempelmann
Affiliation:
Department of Anaesthesiology, Justus-Liebig-University, Rudolf-Buchheim Str., D-35392 Giessen, Germany
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Abstract

The cardiovascular effects of Org 9487 during isoflurane anaesthesia have been evaluated using three doses around its ED90 for neuromuscular blockade, i.e. 1 mg kg−1, 2 mg kg−1 and 3 mg kg−1. Heart rate increased to 110%, 115% and 118% in patients receiving 1 mg kg−1, 2 mg kg−1 and 3 mg kg−1 respectively. There were no significant effects on systolic and diastolic blood pressures for the two lower dose groups. Patients receiving Org 9487 3 mg kg−1 displayed significant decreases in systolic and diastolic blood pressures (91% and 82% of the control values respectively). Except for heart rate in the group receiving 3 mg kg−1, all measurements returned to baseline after a maximum of 15 min. Six patients experienced a transient increase in airway pressure after administration of Org 9487, which was accompanied by a decrease in oxygen saturation in two out of six subjects, but there was no audible wheezing. These episodes were self-limiting and required no treatment. There were no other adverse reactions to this drug during this study.

Keywords

neuromuscular relaxantOrg 9487cardiovascular effects
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 15 , Issue 5 , September 1998 , pp. 585 - 589
Copyright
1998 European Society of Anaesthesiology

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