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Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy

Published online by Cambridge University Press:  16 August 2006

M. Boussofara ,
D. Bracco  and
P. Ravussin
M. Boussofara
Affiliation:
Institute Salah Azaiz, Tunis, Tunisia and Département d'anesthésiolgie et de réanimation, Hôpital régional de Sion, Sion, Switzerland
D. Bracco
Affiliation:
Institute Salah Azaiz, Tunis, Tunisia and Département d'anesthésiolgie et de réanimation, Hôpital régional de Sion, Sion, Switzerland
P. Ravussin
Affiliation:
Institute Salah Azaiz, Tunis, Tunisia and Département d'anesthésiolgie et de réanimation, Hôpital régional de Sion, Sion, Switzerland
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Abstract

Background and objective This study compares the effect of oral clonidine vs. hydroxyzine on the haemodynamic and catecholamine responses to microlaryngoscopy.

Methods Thirty-five ASA II-III patients were included in this double-blind randomized trial. The patients received either hydroxyzine 1 mg kg−1 (n=18) or clonidine 3 μg kg−1 (n = 17) for their oral premedication 100 min before an intravenous induction of anaesthesia using propofol (2–3 mg kg−1) and fentanyl (2 μg kg−1). Arterial pressure and heart rate were measured before premedication, and throughout the procedure and recovery. Plasma catecholamine levels were determined before premedication, after induction, and 1.5, 30 and 120 min after laryngoscopy.

Results Mean arterial pressure was significantly lower after clonidine, whereas there was no difference in heart rate and plasma catecholamine levels between the two groups.

Conclusions Clonidine for premedication significantly decreased mean arterial pressure during microlaryngoscopy and the following recovery phase but did not modify the overall haemodynamic response to the suspension microlaryngoscopic nociceptive stimulus.

Keywords

sympathetic nervous systemadrenergic alpha-agonistsclonidinehaemodynamicsblood pressureheart rate
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue 2 , February 2001 , pp. 75 - 78
Copyright
2001 European Society of Anaesthesiology

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