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Do muscle relaxants influence vascular tone in isolated coronary artery segments?

Published online by Cambridge University Press:  16 August 2006

A. P. Klockgether-Radke ,
A. Haemmerle ,
D. Kettler  and
G. Hellige
A. P. Klockgether-Radke
Affiliation:
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August University of Göttingen, Göttingen, Germany
A. Haemmerle
Affiliation:
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August University of Göttingen, Göttingen, Germany
D. Kettler
Affiliation:
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August University of Göttingen, Göttingen, Germany
G. Hellige
Affiliation:
Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August University of Göttingen, Göttingen, Germany
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Abstract

The aim of this study was to elucidate the influence of four neuromuscular blocking substances on coronary vascular tone using the model of isolated porcine coronary artery segments. We studied the effects of four muscle relaxants, atracurium, pancuronium, rocuronium, and vecuronium (0.1, 1, and 10 μg mL−1 each), on the contractile response to three vasoconstrictors: acetylcholine, histamine, and serotonin. None of the neuromuscular blocking agents under investigation exerted a significant influence on the vasoconstricting effects of these mediators except for pancuronium, which dose-dependently attenuated acetylcholine-mediated contractions (−10.8% attenuation for 10 μg mL−1 pancuronium, P < 0.05). There was no difference between vessels with intact endothelium and denuded preparations. It is concluded that high-dose pancuronium exerts an antimuscarinic effect in vascular smooth muscle. The other neuromuscular agents studied do not alter vascular reactivity of isolated porcine coronary arteries.

Keywords

neuromuscular non-depolarizing agentsatracuriumpancuroniumrocuroniumvecuroniumarteriescoronary vesselsendothelium
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 17 , Issue 8 , August 2000 , pp. 481 - 484
Copyright
2000 European Society of Anaesthesiology

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