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Does etomidate increase postoperative nausea? A double-blind controlled comparison of etomidate in lipid emulsion with propofol for balanced anaesthesia

Published online by Cambridge University Press:  16 August 2006

M. St Pierre ,
M. Dunkel ,
A. Rutherford  and
W. Hering
M. St Pierre
Affiliation:
Department of Anaesthesiology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
M. Dunkel
Affiliation:
Department of Anaesthesiology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
A. Rutherford
Affiliation:
Department of Anaesthesiology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
W. Hering
Affiliation:
Department of Anaesthesiology, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
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Abstract

In a double-blind randomized study, the incidence and severity of postoperative nausea and vomiting was investigated with a new formulation of etomidate (Etomidate-®Lipuro, B. Braun Melsungen AG, Germany) compared with propofol for induction of a balanced anaesthesia with isoflurane/fentanyl in air.

The incidence and intensity of nausea was examined by use of a visual analogue scale (VAS; 0–100 mm) at 1, 2, between 6 and 8, and 24 h postoperatively. One-hundred-and-sixty-four patients undergoing orthopedic procedures were studied. For etomidate vs. propofol, 14.6% vs. 14.2% male and 26.8% vs. 27.5% female patients were nauseated during the first two postoperative hours. The median rating for nausea remained below 5 mm at any time in both groups, i.e. the intensity of nausea was very low. The incidence of vomiting was higher in women receiving etomidate (26.8% vs. 10%).

We conclude that etomidate does not increase nausea during the early postoperative period.

Keywords

anaesthetic techniquesbalanced anaesthesiaheterocyclic compoundsimidazolesetomidateorganic chemicalsphenolspropofolpostoperative nausea and vomiting
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 17 , Issue 10 , October 2000 , pp. 634 - 641
Copyright
2000 European Society of Anaesthesiology

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