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Dopamine delays gastric emptying and prolongs orocaecal transit time in volunteers

Published online by Cambridge University Press:  16 August 2006

N. G. Levein ,
S. E. Thörn  and
M. Wattwil
N. G. Levein
Affiliation:
Department of Anesthesiology and Intensive Care, Örebro Medical Center Hospital, S-701 85 Örebro, Sweden
S. E. Thörn
Affiliation:
Department of Anesthesiology and Intensive Care, Örebro Medical Center Hospital, S-701 85 Örebro, Sweden
M. Wattwil
Affiliation:
Department of Anesthesiology and Intensive Care, Örebro Medical Center Hospital, S-701 85 Örebro, Sweden
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Abstract

Dopamine decreases gastric tone and may therefore influence gastrointestinal motility. The aim of this investigation was to study the effects of a continuous infusion of dopamine on gastric emptying and orocaecal transit time. Nine healthy male volunteers were studied on two occasions in a randomized order. All volunteers received on separate days a continuous infusion of dopamine 5 μg kg−1 min−1 on one occasion and normal saline on the other occasion. Gastric emptying was measured by the paracetamol absorption test and orocaecal transit time by the hydrogen breath test. During the dopamine infusion the area under the paracetamol concentration curve was significantly smaller than during control conditions (P=0.02). Orocaecal transit time was prolonged during the dopamine infusion (P=0.02). Dopamine delays gastric emptying and prolongs orocaecal transit time.

Keywords

dopaminegastric emptyingparacetamolorocaecal transit timehydrogen breath test
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 4 , April 1999 , pp. 246 - 250
Copyright
1999 European Society of Anaesthesiology

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