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Doxapram and aminophylline on bispectral index under sevoflurane anaesthesia: a comparative study

Published online by Cambridge University Press:  08 August 2006

C.-C. Wu ,
C.-S. Lin ,
G.-J. Wu ,
Y.-H. Lin ,
Y.-W. Lee ,
J.-Y. Chen  and
M. S. Mok
C.-C. Wu
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
C.-S. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
G.-J. Wu
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-H. Lin
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
Y.-W. Lee
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
J.-Y. Chen
Affiliation:
Shin-Kwon Wu Ho Su Memorial Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
M. S. Mok
Affiliation:
Taipei Medical University Hospital, Department of Anesthesiology, Taipei, Taiwan, ROC
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Abstract

Summary

Background and objective: To evaluate and compare the effect of two clinically available central nervous system stimulants, namely doxapram and aminophylline on arousal from sevoflurane anaesthesia and bispectral index. Methods: This randomized, double-blind, placebo-controlled, prospective study was conducted in 90 adult females, ASA I–II, scheduled for elective lower abdominal surgeries at Taipei Medical University Hospital. At 5 min before the completion of surgery, under sevoflurane anaesthesia, patients were divided into three groups to receive doxapram 1 mg kg−1, aminophylline 2 mg kg−1 or saline placebo intravenous. Standard vital signs, end-tidal CO2, end-expiratory sevoflurane concentration, bispectral index and neuromuscular blockade were measured plus clinical parameters of recovery from general anaesthesia. Results: Compared with the control group, patients receiving doxapram or aminophylline showed a similarly faster recovery from sevoflurane anaesthesia correlated with increase in bispectral index. Conclusion: Intravenous administration of doxapram 1 mg kg−1 or aminophylline 2 mg kg−1 hastened the early recovery from sevoflurane anaesthesia. The arousal effect of aminophylline and doxapram appears to be similar.

Keywords

ANAESTHESIA, GENERALANAESTHETICS INHALATIONAL, sevofluraneDOXAPRAMAMINOPHYLLINE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 11 , November 2006 , pp. 937 - 941
Copyright
2006 European Society of Anaesthesiology

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