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The effect of nitric oxide on fentanyl and haloperidol-induced catalepsy in mice

Published online by Cambridge University Press:  01 March 2006

U. Erkent ,
A. B. Iskit ,
R. Onur  and
M. Ilhan
U. Erkent
Affiliation:
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
A. B. Iskit
Affiliation:
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
R. Onur
Affiliation:
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
M. Ilhan
Affiliation:
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
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Extract

Summary

Background and objectives: This study was designed to investigate the role of nitric oxide on catalepsy induced by fentanyl and haloperidol. Methods: Male albino mice were treated either with fentanyl (0.1–0.2 mg kg−1, s.c.) or haloperidol (0.5–2 mg kg−1, i.p.). The non-selective nitric oxide synthase inhibitor, NG-nitro-l-arginine (10 mg kg−1, i.p.), selective neuronal nitric oxide synthase inhibitor, 7-nitroindazole (3 mg kg−1, i.p.), and nitric oxide donors, l-arginine (30–300 mg kg−1, i.p.) and d-arginine (30 mg kg−1, i.p.), were applied 20 min prior to fentanyl or haloperidol injection. A μ-opioid receptor antagonist naloxone (1 mg kg−1, i.p.) was also given in some groups. The cataleptic status of mice was assessed by placing animals in a rearing position in the cage. If the mouse maintained cataleptic posture for more than 20 s, it was scored as cataleptic and duration of catalepsy was expressed in terms of minutes. Results: Both NG-nitro-l-arginine and 7-nitroindazole prolonged fentanyl-induced catalepsy (fentanyl: 3.6 ± 0.8 min; fentanyl + NG-nitro-l-arginine: 77.4 ± 14.6 min, fentanyl + 7-nitroindazole: 56.0 ± 10.4 min; n = 6; P < 0.01). This effect was reversed by l-arginine and naloxone, but not by d-arginine. Nitric oxide synthase inhibitors also prolonged the cataleptic action of haloperidol but to a lesser extent (haloperidol: 72.0 ± 6.3 min; haloperidol + NG-nitro-l-arginine: 98.5 ± 6.3 min, haloperidol + 7-nitroindazole: 89.6 ± 2.2 min; n = 6; P < 0.05). The prolongation of haloperidol-induced catalepsy with nitric oxide synthase inhibitors was not reversed by l-arginine. Conclusion: These results suggest a common mechanism between μ-opioid receptors and the nitric oxide system in the development of fentanyl-induced catalepsy in mice different from haloperidol-induced catalepsy.

Keywords

FENTANYL, HALOPERIDOL, NITRIC OXIDE OPIOID, DOPAMINE, CATALEPSY
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 7 , July 2006 , pp. 580 - 585
Copyright
© 2006 European Society of Anaesthesiology

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Footnotes

Preliminary account of the present data was presented in abstract form at the XVII. Biannual Meeting of the Turkish Pharmacological Society in October, 2003, Belek-Antalya.

References

Porreca F, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. J Pharmacol Exp Ther 1992; 263: 147–152.Google Scholar
Malec D, Fidecka S, Langwinski R. Central action of narcotic analgesics. I Catalepsy and stereotypy in rats and narcotic analgesics. Pol J Pharmacol Phar 1977; 29: 177–193.Google Scholar
Banerjee U, Burks TF, Feldberg W, Goodrich CA. Temperature effects and catalepsy produced by morphine injected into the cerebral ventricles of rabbits. Br J Pharmacol 1968; 33: 544–551.Google Scholar
Van der Wende C, Spoerlein MT. Morphine-induced catalepsy in mice. Modification by drugs acting on neurotransmitter system. Neuropharmacology 1979; 18: 633–637.Google Scholar
Havemann U, Winkler M, Kuschinsky K. Opioid receptors in the caudate nucleus can mediate EMG-recorded rigidity in rats. N-S Arch Pharmacol 1980; 313: 139–144.Google Scholar
Afify EA, Daabes TT, Gabra BH, Abou Zeit-Har MS. Role of nitric oxide in catalepsy and hyperthermia in morphine-dependent rats. Pharmacol Res 2001; 44: 533–539.Google Scholar
Ling GS, Pasternak GW. Morphine catalepsy in the rat: involvement of mu 1 (high affinity) opioid binding sites. Neurosci Lett 1982; 32: 193–196.Google Scholar
Ignarro IL. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 1990; 30: 535–560.Google Scholar
Sandi C, Venero C, Guaza C. Decreased spontaneous motor activity and startle response in nitric oxide synthase inhibitor-treated rats. Eur J Pharmacol 1995; 277: 89–97.Google Scholar
Dzoljic E, De Vries R, Dzoljic MR. New and potent inhibitors of nitric oxide synthase reduce motor activity in mice. Behav Brain Res 1997; 87: 209–212.Google Scholar
Zarrindast MR, Gholami A, Sahraei H, Haeri-Rohani A. Role of nitric oxide in the acquisition and expression of apomorphine- or morphine-induced locomotor sensitization. Eur J Pharmacol, 2003; 482: 205–213.Google Scholar
Noda Y, Yamada K, Furukawa H, Nabeshima T. Involvement of nitric oxide in phencyclidine-induced hyperlocomotion in mice. Eur J Pharmacol 1995; 286: 291–297.Google Scholar
Abekawa T, Ohmori T, Koyama T. Effect of NO synthase inhibition on behavioral changes induced by a single administration of methamphetamine. Brain Res 1994; 666: 147–150.Google Scholar
Starr BS, Starr MS. Motor actions of 7-OH-DPAT in normal and reserpine-treated mice suggest involvement of both dopamine D2 and D3 receptors. Eur J Pharmacol 1995; 277: 151–158.Google Scholar
Dall'Igna OP, Dietrich MO, Hoffmann A et al. Catalepsy and hypolocomotion induced by nitric oxide donor: attenuation by theophylline. Eur J Pharmacol 2001; 432: 29–33.Google Scholar
Bashkatova V, Alam M, Vanin A, Schmidtb WJ. Chronic administration of rotenone increases levels of nitric oxide and lipid peroxidation products in rat brain. Exp Neurol 2004; 186: 235–241.Google Scholar
Buyukuysal RL. Effect of nitric oxide donors on endogenous dopamine release from rat striatal slices. II: The role of voltage-dependent sodium channels, calcium channel activation, reverse transport mechanism, guanylate cyclase and endogenous glutamate. Fundam Clin Pharmacol 1997; 11: 528–536.Google Scholar
Wauquier A, Niemegeers CJ, Lal H. Differential antagonism by the antichlolinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation. Psychopharmacologia 1975; 41: 229–235.Google Scholar
Liang LP, Kaufman S. The regulation of dopamine release from striatum slices by tetrahydrobiopterin and l-arginine-derived nitric oxide. Brain Res 1998; 800: 181–186.Google Scholar
Sandor NT, Brassai A, Puskas A, Lendvai B. Role of nitric oxide in modulating neurotransmitter release from rat. Brain Res Bull 1995; 36: 483–486.Google Scholar
Marras RA, Martins AP, Del Bel EA, Guimaraes FS. l-NOARG, an inhibitor of nitric oxide synthase, induces catalepsy in mice. Neuroreport 1995; 7: 158–160.Google Scholar
Desvignes C, Bert L, Vinet L, Denoroy L, Renaud B, Lambás-Seňas L. Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamin oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxy phenylacetic acid. Neurosci Lett 1999; 261: 175–178.Google Scholar
Adams MR, Brandon EP, Chartoff EH, Idzerda RL, Dorsa DM, McKnight GS. Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci USA 1997; 94: 12 157–12 161.Google Scholar
Sanberg PR, Bunsey MD, Giordano M, Norman AB. The catalepsy test: its ups and downs. Behav Neurosci 1988; 102: 748–759.Google Scholar
Pires JG, Fonseca FC, Woelffel AB, Futuro-Neto HA. Evidence of interaction between fluoxetine and isosorbide dinitrate on neuroleptic-induced catalepsy in mice. Braz J Med Biol Res 1998; 31: 417–420.Google Scholar
Chen SW, Maguire PA, Davies MF, Beatty MF, Loew GH. Evidence for mu1-opioid receptor involvement in fentanyl-mediated respiratory depression. Eur J Pharmacol 1996; 312: 241–244.Google Scholar
Ezrin-Waters C, Seeman P. Tolerance of haloperidol catalepsy. Eur J Pharmacol 1997; 41: 321–327.Google Scholar
Del Bel EA, Guimarães FS. Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and of NADPH-diaphorase neurons in mice. Psychopharmacology 2000; 47: 356–361.Google Scholar
Del Bel EA, Souza AS, Guimarães FS, Silva CA, Silva LP. Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice. Psychopharmacology 2002; 161: 32–37.Google Scholar
Morris BJ, Simpson CS, Mundell S, Maceachern K, Johnston HM, Nolan AM. Dynamic changes in NADPH-diaphorase staining reflect activity of nitric oxide synthase: evidence for a dopaminergic regulation of striatal nitric oxide release. Neuropharmacology 1997; 36: 1589–1599.Google Scholar
Liang LP, Kaufman S. The regulation of dopamine release from striatum slices by tetrahydrobiopterin and l-arginine-derived nitric oxide. Brain Res 1998; 800: 181–186.Google Scholar
West AR, Grace AA. Striatal nitric oxide signaling regulates the neuronal activity of midbrain dopamine neurons in vivo. J Neurophysiol 2000; 83: 1796–1808.Google Scholar
West AR, Galloway MP. Endogenous nitric oxide facilitates striatal dopamine and glutamate efflux in vivo: role of ionotropic glutamate receptor-dependent mechanisms. Neuropharmacology 1997; 36: 1571–1581.Google Scholar
Kiss JP, Zsilla G, Vizi ES. Inhibitory effect of nitric oxide on dopamine transporters: interneuronal communication without receptors. Neurochem Int 2004; 45: 485–489.Google Scholar
Araki T, Mizutani H, Matsubara M, Imai Y, Mizugaki M, Itoyama Y. Nitric oxide synthase inhibitors cause motor deficits in mice. Eur J Neuropsychopharmacol 2001; 11: 125–133.Google Scholar
Gupta M, Balakrishnan S, Pandhi P. Role of nitric oxide in experimental models of psychosis in rats. Method Find Exp Clin Pharmacol 2001; 23: 497–500.Google Scholar
Segovia G, Mora F. Role of nitric oxide in modulating the release of dopamine, glutamate, and GABA in striatum of the freely moving rat. Brain Res Bull 1998; 45: 275–279.Google Scholar