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Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol

Published online by Cambridge University Press:  16 August 2006

A. Furuya ,
T. Matsukawa ,
M. Ozaki ,
T. Nishiyama ,
M. Kume  and
T. Kumazawa
A. Furuya
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
T. Matsukawa
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
M. Ozaki
Affiliation:
Department of Anaesthesia, Tokyo Women's Medical University
T. Nishiyama
Affiliation:
Surgical Center, The Institute of Medical Science, The University of Tokyo, Tokyo
M. Kume
Affiliation:
Department of Anaesthesia, Kofu Municipal Hospital, Kofu, Japan
T. Kumazawa
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
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Abstract

Background and objective To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure.

Methods Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthesia was induced with 2 mg kg−1 propofol and 0.5 mg kg−1 ketamine or 2 mg kg−1 propofol alone. Ketamine was administered 1 min prior to induction with propofol. Immediately after induction with propofol, vecuronium (0.15 mg kg−1) was administered. Four minutes after administration of vecuronium, tracheal intubation was performed. Anaesthesia was maintained using sevoflurane (0.5%) in 66% nitrous oxide until 3 min after intubation. Systolic, diastolic and mean arterial pressure and heart rate were recorded on arrival, directly before induction with propofol, prior to tracheal intubation, immediately after intubation and at 3 min after intubation.

Results and conclusions Administration of ketamine before induction with propofol preserved haemodynamic stability compared with induction with propofol alone.

Keywords

anaestheticsintravenousketaminepropofolhaemodynamicsblood pressuredrug effects
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue 2 , February 2001 , pp. 88 - 92
Copyright
2001 European Society of Anaesthesiology

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