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Neurotoxicity with single dose intrathecal midazolam administration

Published online by Cambridge University Press:  25 November 2005

B. Ugur ,
K. Basaloglu ,
T. Yurtseven ,
U. Ates ,
O. N. Aydin ,
D. Özenç ,
M. Yurtseven  and
A. Gürel
B. Ugur
Affiliation:
Adnan Menderes University Medical Faculty, Department of Anaesthesiology and Reanimation, Aydin, Turkey
K. Basaloglu
Affiliation:
Adnan Menderes University Medical Faculty, Department of Histology and Embryology, Aydin, Turkey
T. Yurtseven
Affiliation:
Ege University Medical Faculty, Department of Neurosurgery, Izmir, Turkey
U. Ates
Affiliation:
Ege University Medical Faculty, Department of Histology and Embryology, Izmir, Turkey
O. N. Aydin
Affiliation:
Adnan Menderes University Medical Faculty, Department of Anaesthesiology and Reanimation, Aydin, Turkey
D. Özenç
Affiliation:
Ege University Medical Faculty, Department of Neurosurgery, Izmir, Turkey
M. Yurtseven
Affiliation:
Ege University Medical Faculty, Department of Histology and Embryology, Izmir, Turkey
A. Gürel
Affiliation:
Adnan Menderes University Medical Faculty, Department of Anaesthesiology and Reanimation, Aydin, Turkey
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Extract

Summary

Background and objective: The aim of study was to investigate the electron microscopic changes in the medulla of the spinal cord that occur with intrathecal midazolam administration. Methods: Twenty-eight albino rabbits of New Zealand type were randomized into two groups. Following anaesthesia, 16 rabbits were given 300 μg of midazolam (Group M) and 12 rabbits were given 0.3 mL of normal saline solution (Group C) intrathecally. Eight rabbits from Group M (Group M1) and 6 rabbits from Group C (Group C1) were sacrificed 24 h after the anaesthesia and 8 rabbits from Group M (Group M2) and 6 rabbits from Group C (Group C2) were sacrificed 6 days after the anaesthesia. The lumbosacral portion was removed by laminectomy and thin sections were examined microscopically. Results: Severe separation in myelin lamella of the large axons, honeycomb appearance, slight separation in myelin lamella of small to moderately large axons, degenerate vacuoles in the cytoplasm and nuclear membrane irregularity were observed in neurons of Groups M1 and M2. Myelin lamella and nuclear membranes were found to be regular, vacuoles and oedema were observed in the neurons in the Groups C1 and C2. Conclusion: Midazolam administered at single dose by the intrathecal route may have neurotoxic effects on the neurons and myelinated axons at 24 h and 6 days following administration.

Keywords

MICROSCOPY ELECTRONMIDAZOLAMINJECTIONS SPINAL, intrathecalNEUROTOXICITYRABBITS
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 12 , December 2005 , pp. 907 - 912
Copyright
© 2005 European Society of Anaesthesiology

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