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Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol

Published online by Cambridge University Press:  02 June 2005

D. Harmon ,
C. Rozario  and
D. Lowe
D. Harmon
Affiliation:
University College Hospital, Department of Anaesthesia, Galway, Ireland
C. Rozario
Affiliation:
University College Hospital, Department of Anaesthesia, Galway, Ireland
D. Lowe
Affiliation:
University College Hospital, Department of Anaesthesia, Galway, Ireland
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Abstract

Summary

Background and objective: The incidence of pain associated with the injection of propofol still remains a problem. This study sought to examine the analgesic effects of inhaled nitrous oxide in oxygen on the prevention of propofol injection pain.

Methods: Nitrous oxide in oxygen was compared with a lidocaine (20 mg)–propofol mixture and with propofol alone (control) in a prospective, randomized, observer-blinded study. ASA I and II patients (n = 135) scheduled for elective surgical procedures were studied. A standard propofol injection technique and scoring system to measure the pain on injection was used.

Results: Demographic variables were similar between the study groups. Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14–52%, P = 0.001) and lidocaine groups (95% CI: 14–52%, P = 0.001).

Conclusions: The inhalation of a nitrous oxide/oxygen mixture significantly reduces the incidence of pain during propofol injection. This therapeutic stratagem was as effective as a lidocaine–propofol mixture.

Keywords

ANAESTHETICS, INTRAVENOUS, propofolANAESTHETICS, LOCAL, lidocaineINORGANIC CHEMICALS, nitrous oxideNERVOUS SYSTEM PHYSIOLOGY, SENSATION, painPERIPHERAL NERVOUS SYSTEM AGENTS, SENSORY SYSTEM AGENTS
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 2 , February 2003 , pp. 158 - 161
Copyright
2003 European Society of Anaesthesiology

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