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Postoperative pain management with intravenous patient-controlled morphine: comparison of the effect of adding magnesium or ketamine

Published online by Cambridge University Press:  30 June 2005

H. Ünlügenç ,
M. Özalevli ,
T. Güler  and
G. Işik
H. Ünlügenç
Affiliation:
Çukurova University, Department of Anaesthesiology, Faculty of Medicine, Adana, Turkey
M. Özalevli
Affiliation:
Çukurova University, Department of Anaesthesiology, Faculty of Medicine, Adana, Turkey
T. Güler
Affiliation:
Çukurova University, Department of Anaesthesiology, Faculty of Medicine, Adana, Turkey
G. Işik
Affiliation:
Çukurova University, Department of Anaesthesiology, Faculty of Medicine, Adana, Turkey
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Extract

Summary

Background and objective: This double-blind randomized study tested whether the addition of magnesium or ketamine to morphine for intravenous patient-controlled analgesia resulted in improved analgesic efficacy and lower pain scores compared with morphine patient-controlled analgesia alone after major abdominal surgery.

Methods: Ninety patients (3 × 30) were randomly allocated to receive either morphine 0.4 mg mL−1 (Group M) by patient-controlled analgesia, morphine 0.4 mg mL−1 + MgSO4 30 mg mL−1 (Group MM) or morphine 0.4 mg mL−1 + ketamine 1 mg mL−1 (Group MK). Postoperative analgesia was started when the verbal rating scale was ≥2. Patients were first given a standardized loading dose (0.05 mg kg−1) of the study solution. They were then allowed to use bolus doses of this solution (0.0125 mg kg−1 every 20 min without time limit). Discomfort, sedation, pain scores, cumulative morphine consumption and adverse effects were recorded up to 24 h after the start of the patient-controlled analgesia.

Results: The level of discomfort, level of sedation and verbal rating scores decreased significantly with time in all groups (P < 0.05). Both verbal rating and discomfort scores were significantly lower in Groups MM and MK at 15, 30 and 60 min compared with Group M (P < 0.001). Cumulative morphine consumption after 12 and 24 h was significantly higher in Group M alone (median 26 and 49 mg, respectively) compared with Group MM (24.2 and 45.7 mg) and Group MK (24.4 and 46.5 mg).

Conclusions: In the immediate postoperative period, the addition of magnesium or ketamine to morphine for intravenous patient-controlled analgesia led to a significantly lower consumption of morphine. However, these differences are unlikely to be of any clinical relevance.

Keywords

ANALGESIA, patient-controlledANALGESICS, ketamineANALGESICS, OPIOID, morphineEXCITATORY AMINO ACID ANTAGONISTSMETALS, LIGHT, magnesiumPAIN, postoperative
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 5 , May 2003 , pp. 416 - 421
Copyright
2003 European Society of Anaesthesiology

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