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Preoperatively administered ramosetron oral disintegrating tablets for preventing nausea and vomiting associated with patient-controlled analgesia in breast cancer patients

Published online by Cambridge University Press:  01 September 2008

H.-J. Lee ,
J.-Y. Kwon ,
S.-W. Shin ,
C.-H. Kim ,
S.-H. Baek ,
S.-W. Baik ,
H.-K. Kim  and
K.-H. Kim
H.-J. Lee
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
J.-Y. Kwon*
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
S.-W. Shin
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
C.-H. Kim
Affiliation:
Pusan National University, School of Dentistry, Department of Dental Anesthesia and Pain Medicine, Busan, Republic of Korea
S.-H. Baek
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
S.-W. Baik
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
H.-K. Kim
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
K.-H. Kim
Affiliation:
Pusan National University, Medical Research Institute, School of Medicine, Department of Anesthesia and Pain Medicine, Busan, Republic of Korea
*
Correspondence to: Jae-Young Kwon, Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, 1-10, Ami-dong, Seo-gu, Busan, 602-739, Republic of Korea. E-mail: lhjksk@pusan.ac.kr; Tel: +82 51 240 7399; Fax: +82 51 242 7466
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Summary

Background and objectives

The purpose of this study was to investigate the acceptability and therapeutic efficacy of a preoperative single administration of long-acting 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist in an orally disintegrating tablet formulation, ramosetron, in breast cancer patients.

Methods

Two hundred and forty women, ASA I-II, aged 24–60 yr, undergoing elective breast cancer surgery, were randomized. A standardized anaesthetic technique was used. Patients were assigned to receive one of three treatment regimens (n = 80 in each group): no prophylactic antiemetics (Group A), single prophylactic intravenous injection of ramosetron 0.1 mg at the completion of surgery (Group B) or preoperatively oral administration of 0.1 mg of ramosetron (Group C). Episodes of nausea and vomiting, the use of rescue antiemetic treatment, degree of pain, adverse events and level of satisfaction were recorded.

Results

The overall incidence of nausea and vomiting during the first 24 h after the recovery in Groups B (27.8%) and C (25%) was decreased significantly compared with Group A (75.3%). The frequency of the use of rescue antiemetics was significantly lower in Group C (5.0%) compared with Groups A (53.2%) and B (15.2%). The patients in Group C were more satisfied with control of postoperative nausea and vomiting than others.

Conclusion

Preoperative oral administration of ramosetron at a dose of 0.1 mg is an acceptable and effective way of reducing the incidence of postoperative nausea and vomiting in breast cancer patients.

Keywords

BREAST SURGERYORAL ADMINISTRATIONPOSTOPERATIVE NAUSEA AND VOMITINGPREMEDICATIONRAMOSETRON
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 25 , Issue 9 , September 2008 , pp. 756 - 762
Copyright
Copyright © European Society of Anaesthesiology 2008

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