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A randomized controlled double-blind trial comparing piritramide and morphine for analgesia after hysterectomy

Published online by Cambridge University Press:  16 August 2006

U. R. Döpfmer ,
M. R. Schenk ,
S. Kuscic ,
D. H. Beck ,
S. Döpfmer  and
W. J. Kox
U. R. Döpfmer
Affiliation:
Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin
M. R. Schenk
Affiliation:
Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin
S. Kuscic
Affiliation:
Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin
D. H. Beck
Affiliation:
Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin
S. Döpfmer
Affiliation:
Lindenstr. 30, 12589 Berlin, Germany
W. J. Kox
Affiliation:
Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin
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Abstract

Background and objective Efficacy and side–effects of piritramide (pirinitramide) and morphine, given intravenously for postoperative analgesia after hysterectomy, were compared in a randomized controlled double-blind trial in 92 ASA class I–III patients.

Methods Administration was investigator–controlled during the first 90 min and subsequently via a patientcontrolled device. Visual analogue scales for pain intensity and verbal rating scales for side-effects were taken repeatedly.

Results Median visual analogue scores for pain intensity on a 100-mm scale 4, 8 and 24 h after surgery were 10, 8.5 and 5mm in the piritramide group and 18, 10 and 8.5mm in the morphine group. These differences are neither statistically nor clinically significant. Median values for nausea on a verbal rating scale from 0 to 3 were zero for both groups at all times with similar ranges. There was no difference in number of episodes of vomiting and retching and usage of antiemetics. The mean amount of piritramide used for initial titration was 15.2 mg; the respective amount of morphine was 15.4 mg.

Conclusions In this setting the two agents are equally effective and show a similar profile of sideeffects.

Keywords

analgesiapatient controlledanalgesicsopioidpirinitramidemorphinenauseapostoperative nausea and vomitingrandomized controlled trials
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue 6 , June 2001 , pp. 389 - 393
Copyright
2001 European Society of Anaesthesiology

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