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Thiopentone and propofol: a compatible mixture?

Published online by Cambridge University Press:  16 August 2006

H. G. W. Paw ,
M. Garrood ,
A. J. Fillery-Travis  and
G.T. Rich
H. G. W. Paw
Affiliation:
Department of Anaesthesia, James Paget Hospital, Lowestoft Road, Gorleston, Great Yarmouth NR31 6LA, UK
M. Garrood
Affiliation:
Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
A. J. Fillery-Travis
Affiliation:
Department of Anaesthesia, James Paget Hospital, Lowestoft Road, Gorleston, Great Yarmouth NR31 6LA, UK Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
G.T. Rich
Affiliation:
Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
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Abstract

The physical compatibility of thiopentone and propofol mixtures was investigated. The investigations used were macroscopic and microscopic observations, zeta potential and oil droplet size measurements. There was no evidence of instability in the mixtures. The thiopentone–propofol mixture has the potential advantage of reducing the pain on injection, provides synergistic interaction, does not prolong recovery when used for induction of anaesthesia, may reduce the incidence of convulsions and is cost-effective.

Keywords

anaesthetics intravenousthiopentonepropofol
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 15 , Issue 4 , July 1998 , pp. 409 - 413
Copyright
1998 European Society of Anaesthesiology

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