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Disfunción sexual en pacientes con esquizofrenia tratados con antipsicóticos

Published online by Cambridge University Press:  12 May 2020

Alp Üçok ,
Cern Incesu ,
Tamer Aker  and
Şahap Erkoç
Alp Üçok
Affiliation:
Universidad de Estambul, Facultad de Medicina de Estambul, Departamento de Psiquiatría, Millet Street, Capa 34390, Estambul, Turquía
Cern Incesu
Affiliation:
Hospital Acibadem, Departamento de Psiquiatría, Estambul, Turquía
Tamer Aker
Affiliation:
Universidad Kocaeli, Facultad de Medicina Kocaeli, Izmit, Turquía
Şahap Erkoç
Affiliation:
Hospital Estatal para los Trastornos Mentales Bakirköy, Estambul, Turquía
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Resumen

Objetivo

El objetivo de este estudio fue determinar la prevalencia de disfunción sexual en pacientes con esquizofrenia tratados con antipsicóticos e investigar el efecto de varios parámetros sobre la disfunción sexual.

Método

Se seleccionaron para el estudio 827 pacientes estabilizados que estaban siendo tratados de forma ambulatoria y que cumplieron los criterios de esquizofrenia del DSM-IV. Se aplicaron la Escala de Experiencias Sexuales de Arizona (ASEX) y la subescala de función sexual de la Escala de Puntuación de Efectos Secundarios UKU en una sola entrevista.

Resultados

En total, el 52,6% de los pacientes tenía disfunción sexual, el 54,2% refirió poco deseo sexual y el 41,7%, dificultad para experimentar un orgasmo. Tenían disfunción eréctil y problemas de eyaculación el 48,1% y el 64,2% de los hombres, respectivamente; el 24,9% de las mujeres tenía amenorrea. Se encontró una correlación entre la puntuación ASEX y la gravedad de la enfermedad (p = 0,02). Los pacientes que fumaban tenían puntuaciones ASEX más altas (p = 0,01). Los hombres que recibían monoterapia atípica tuvieron unas puntuaciones ASEX más bajas que los que recibían una combinación de antipsicóticos atípicos y convencionales (p = 0,017). Los pacientes que recibían tratamiento combinado tenían más problemas de eyaculación que el grupo que recibía fármacos atípicos (p = 0,001). El deseo sexual bajo era más frecuente en mujeres que tomaban fármacos convencionales que en los que tomaban fármacos atípicos (p = 0,004). En los análisis de regresión lineal, ASEX varió significativamente y de forma independiente por la gravedad de la enfermedad sólo en hombres (p = 0,005).

Conclusión

Nuestros resultados demuestran que en pacientes con esquizofrenia que toman antipsicóticos es muy frecuente la disfunción sexual. 2007 Elsevier Masson SAS. Reservados todos los derechos.

Keywords

EsquizofreniaDisfunción sexualAntipsicóticos típicosAntipsicóticos atípicosASEX
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 14 , Issue 8 , November 2007 , pp. 393 - 399
Copyright
Copyright © European Psychiatric Association 2007

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