Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-28T14:31:02.840Z Has data issue: false hasContentIssue false

La leucocitopenia en pacientes tratados con clozapina puede estar inducida por otros fármacos: una serie clinica

Published online by Cambridge University Press:  12 May 2020

Mary Jo Imbarlina
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview
Sonali Sarkar
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Shashi Marwah
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview
Haranath Parepally
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Phillip R. Johnston
Affiliation:
instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Jaspreet S. Brar
Affiliation:
instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
K. N. Roy Chengappa
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Get access

Resumen

La combinación de clozapina y otros medicamentos potencialmente leucocitopénicos puede plantear un riesgo mayor de neutrocitopenia. Sin embargo, la neutrocitopenia puede no deberse siempre a la clozapina. Al añadir medicamentos potencialmente leucocitopénicos, los profesionales clínicos deben buscar posibles alternativas, en especial porque la clozapina es un fármaco que se utiliza a menudo como último recurso en el tratamiento de la esquizofrenia resistente.

Type
Comunicación breve
Copyright
Copyright © European Psychiatric Association 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Imbarlina MJ, Sarkar S, Marwah S, Parepally H, Johnston PR, Brar JS, Chengappa KNR. Leukopenia in clozapine treated patients may be induced by other drugs: a case series. Eur Psychiatry 2004;19:506-509.

References

Bibliografía

[1]Alvir, JMLieberman, JASafferman, AZSchwimmer, JLSchaaf, JA. Clozapine- induced agranalocytosis: incidence and risk factors in the United States. N Engl J Med 1993; 329: 162-7.CrossRefGoogle ScholarPubMed
[2]Brenner, LO. Agranulocytosis and ranitidine (Letter). Ann Intern Med 1986; 104: 896-7.CrossRefGoogle Scholar
[3]Capellari, GGaio, ACavallaro, ACardaioli, CSimioni, L, La Valle R, et al. Use of colony stimulating factors for the treatment of druginduced agranlocytosis. Br J Haematol 1993; 84: 183-4.CrossRefGoogle Scholar
[4]Devinsky, OHonigfeld, GPatin, J. Clozapine related seizures. Neurology 1991; 41: 369-71.CrossRefGoogle ScholarPubMed
[5]Facciola, GAvenoso, AScordo, MGAldo, GVentimiglia, APerucca, E, et al. Small effects of valprotic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. Ther Drug Monit 1999; 21: 341-7.CrossRefGoogle ScholarPubMed
[6]Finley, PWarner, D. Potential impact of valproic acid therapy on clozapine disposition. Biol Psychiatry 1994; 36: 487-8.CrossRefGoogle ScholarPubMed
[7]Kando, JCTohen, MCastillo, JCentorrino, F. Concurrent use of clozapine and valproate in affective and psychotic disorders. J Psychiatry 1994; 55: 255-7.Google ScholarPubMed
[8]Kane, JHonigfeld, GSinger, JMeltzer, H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988; 45: 789-96.Google ScholarPubMed
[9]Lane, GPSpeed, B. Agranulocytosis after ranitidine administration. Med JAust 1989; 150: 595-6.Google ScholarPubMed
[10]Madeb, RHirschmann, SKurs, RTurkie, AModai, I. Combined clozapine and valproic acid treatment induced agranulocytosis. Eur Psychiatry 2002; 17: 238-9.CrossRefGoogle ScholarPubMed
[11]Patton, WN. Use of colony stimulating factors in the treatment of drug-induced agranulocytosis. Br J Haematol 1993,84:184-5.Google Scholar
[12]Patton, WPHolyoake, TLYates, JMBoughton, BJFranklin, IM. Accelerated recovery from drug-induced agranulocytosis following G-CSF therapy. Br J Haematol 1992; 80: 564-5.CrossRefGoogle ScholarPubMed
[13]Peacock, LGerlach, J. Clozapine treatment in Denmark: concomitant psychotropic medication and hematologic monitoring in a System with liberal usage practices. J Clin Psychiatry 1994; 55: 44-9.Google Scholar
[14]Senechal, ALandry, PDeschamps, RLessard, M. Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs. Encephale 2002; 28: 567-9.Google Scholar
[15]Shields, LIFiles, JADoli, DCGreensburg, BR. Ranitidine and agranulocytosis (Letter). Ann Intern Med 1986; 104: 128.CrossRefGoogle Scholar
[16]Watts, RGEmanuel, PDSucherman, KSHoward, TH. Valproic acid induced cytopenia: evidence for a dose-related suppression of hematopoiesis. J Pediatr 1990; 117: 495-9.CrossRefGoogle Scholar
[17]Wilson, WH. Do anticonvulsants hinder clozapine treatment? Biol Psychiatry 1995; 37: 132-3.CrossRefGoogle ScholarPubMed